ID W5M0R9_LEPOC Unreviewed; 3022 AA.
AC W5M0R9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Collagen, type VI, alpha 4a {ECO:0000313|Ensembl:ENSLOCP00000001976.1};
GN Name=COL6A6 {ECO:0000313|Ensembl:ENSLOCP00000001976.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000001976.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000001976.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01012312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000001976; -.
DR Ensembl; ENSLOCT00000001981.1; ENSLOCP00000001976.1; ENSLOCG00000001668.1.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000155619; -.
DR InParanoid; W5M0R9; -.
DR Proteomes; UP000018468; Linkage group LG11.
DR Bgee; ENSLOCG00000001668; Expressed in larva and 12 other cell types or tissues.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd22630; Kunitz_collagen_alpha6_VI; 1.
DR CDD; cd01472; vWA_collagen; 4.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 10.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 10.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 10.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF53300; vWA-like; 11.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50234; VWFA; 10.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..3022
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004865386"
FT TRANSMEM 1294..1319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1331..1361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..209
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 238..411
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 443..618
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 633..807
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 840..1014
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1034..1207
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1369..1542
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1571..1742
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2322..2465
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2531..2732
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2972..3022
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 1971..2280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2788..2815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2025..2040
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2121..2135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2788..2805
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3022 AA; 333091 MW; 660D9A60C22CB293 CRC64;
SSMEMIQFLS AFLFAFCLPV NNAQKTVCTE ETAADIVFLV DGSWSIGTEN FQQIRDFLYA
LIDSFDVGAD KVQIGLIQYS NSPRTEFTLN QYQNKQDILT YIQSLPYKGG GTRTGLGLSY
MLDNHFTEAA GSRVREGVPQ VAIVITDGQS QDTVKQAAEE VKNSGITLYA IGIKEAVLEE
LNEIASDPDD KFVYNVDDFA ALQGISKNFV QVLCTTVEES KRQTLQVSKE CRQATAADIV
FLVDGSTSIG ETNFNEVRNF LYTFVEGLDV GLNKVRVGLA QYSDEVYQEF LLNKYSDKQD
ILEQMQNLQY RTGGTNTGKA LEFLRTQYFT EEAGSRATLG IPQVVIVITD GVSADEVREP
AKKLRENVTV FVVGIGVAAY DELQEIANRP SDKFLFNIDN FEALNQLSSS LLPNVCTSIG
TQKEENQLTP FLVVVIQKPM VLYIVFLVGG STLLGSPAFQ QIRSFISRIV NQLDVGINQH
RVGMAQFSGD TKTEFLLNTY EKRGEVLNHL KNNFRLKGGA QRLGQALNYV HRTFYKESAG
SRIAEGFRQF LIVFTSAKSE DEIQRAARII KAEGVTVISI GLPRAPITEL EVVATKPYVY
QLNSQVFSKT VQEVSGIIES KEAHPCKSAT VADIVFIVDE SASIGTQNFR SVRNFVYKII
DGLDVDLNKV RTGVIMYSDA PRAEVYLNSF REKAEVLRYI KTLPYRGGGT NTGAALDFAR
QNMFVKGRGS RRSQGVQQIA IVITDGESQD NVSGPAVSLQ RAGVTVFALG IKEANMKQLK
QIASYPSRKF VFNVDSFAKL ASVEKSLQKL LCSEIINIAF AAPRVIYSLK EGCVETEEAD
IYFLIDHSGS IDPLGFVDMK KFIKEMIRMF RIGPQSVRIG VVKYANTPTV EFTVTEHTNK
KDLERAVERV QQLGGGTQTG DALRSMSALF QKAASSRNRK TPQFLIVITD GKSQDAVVDA
AKELRAQSIM IYAIGVGDAN EDELLEMSGS PDKKFYVSNF DSLRLIKNEV AQELCSEEAF
FSFFLLVCKT MEADIIFLID SSGSIHPDDY SKMKTFMESM VDRSDIGADK VQVGVLQFSS
VQQEEFPLNK YEDKSGIKQA IYNIQQLGGG TLTGEALKFT SQYFDAARGG RSTVKQFLIV
ITDGEAQDEV AKPAQNLRNK GIIIHTIGVM NANDTQLVEI SGSQDKVHSA KNFDGLQFLE
KNILFQICNP DTGEESGVTL QQNIVESNML KCHCRVHPKS GSMRVLLLEM PEQFQTNLNF
SRLHQYLQNI AKHITGRTEH LLNLPLTVLS QIQYPLYCII FNALLVSICA YFCFTPIYFE
FISLTNKVFK LLTFLLHIIS CYYTVPIIIH FPLYLITFLY IECRTEVADM IFLVDESTTI
DSSEFVSMQK FMIAMVNNSD VGKNRVRFGA IKYSTTPTEM FRLNQFDSKQ QVRDAIAAMT
ADGGDTYTAK ALQFSQTFFT EAYGGRKSAG VPQILLVITD GEATDRYELP KSSMRVREDG
ISIYGIGVEN ATEEELKIMT EDETKVFYVN NFKGLEELQK NITKKLCNDT KPGRQACLLD
YTYSCETKEA DIVMLIDGSG SINPGQFQTM QNFMKDIVGS FRISKTSVQV GVAQFSTEPQ
KEFYLSEFDS EDAIKERILQ MKQMKQSTYI GKALRFIRSF FEPSAGSRIR QFVPQNLIVI
TDGKSIDPVE EAAAELRALN IHIFVISIGY VDALKLQQIA GSNDRLFTVK NFNELETIKK
RVVKNICDPG DEPSTSNCTI DIAVGFDISR RGRFPGLLSS QRKLEAQLLG LIRQMSYLDN
LNCVSASQVI IQIGFLISEN GRIIFDSNFE KYNEEIVRKV MVTLQTMEAT YFTTKLLQSF
LDKFKGKSTA NVKVLLVFSD GLDENVELLE TESENLRRGG INALLTVALE GVTNANDLQM
VEFGRGFGYK VPLAIDMHNI NSAMAKELDT IAERVCCNVM CKCMGQEGLR GPRGPLGIKG
SPGTKGPPGH PGDEGGFGER GTPGLNGTQG IEGCPGKRGI KGPRGYRGNR GEDGDHGIDG
VDGEQGMAGL PGALGERGDP GSPGRSGVRG EPGERGQPGL RGDPGDSGTD NNIRGPKGEK
GNPGIQVAPQ GDAGEDGTPG DAGVDGKRGE RGEPGTPGLR GDPGASGPQG ERGTRGLPGP
PGTLGLPGRQ GELGLQGPKG SVGNEGPKGQ KGQPGDPGVK GSVGPNGPRG LPGIDGRDGY
GSPGQKGEKG ESGFPGYPGP QGEEGDLGTP GSRGPKGSRG RRGNSGSSGV PGDPGIPGAS
GHKVTVVPQF SLFHYFVGDK YWHKSNCFYR IHMTDCPVYP TELVVALDMS EDVTPQVFER
MRNIAVNLLQ DLTISESNCP TGARVAVVSY SSTTKYLIRF SDYHRKKQLI EAIKNIPPKR
TTSRRNIGAA MRFVARNVFK RVRQGVLMRK VAIFISNGAS QEATPIVTAA LEFKALDITP
VVIAFRNVPN VRRAFQVDET GSFLVSVVDR PQNQRTEVQR IQQCALCLDV CNPSEACRIN
LIPAPLQADV DLALVVDSSR NVPTDQYDGV KELLSSILDQ LDVSSQPGTS NRGARVALVQ
HSTLNYPPRR GQAPVRTEFD LLKFKSRNLM KRHISESMQQ LGGSSSTGHA VEWAINNLLL
KAVRPRKAKA VFAFVGGETS YWDRARLGYV ARRAMCQGVA VLAFSVGSDY NDTQVEDLAS
IPLEQHMVHL GQAKLGEIEF AQRFARAFFR VLSTGVNSYP PPALRRECAN IQEPVQQAEI
LETPPIDRIK PKTPPPAEEY YEYTEESESI VEEESEPEEE ITAGPELSQE ETVSQYEETG
RAVEEILFGG ENYLCNTVSQ RQNISDCVNV LCVVLHVNSQ TNACWMWISV AFVGTICKDG
IIIGQSVHAP LSGMAVVAVM RIDLIRNKSH TIQTLAETLQ CKNIRHFSKP QVPSLTPLYR
QDLRLCLKIY FCHKVTLCTV QASPQFFSTD ACTLPKDEGD CRNFTLKWFF DGQQNECSRF
WYGGCGGNRN KFETQEECEA VC
//
