ID W5M186_LEPOC Unreviewed; 309 AA.
AC W5M186;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Ubiquitin recognition factor in ER associated degradation 1 {ECO:0000313|Ensembl:ENSLOCP00000002143.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002143.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000002143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the UFD1 family.
CC {ECO:0000256|ARBA:ARBA00006043}.
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DR EMBL; AHAT01028754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01028755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015221309.1; XM_015365823.1.
DR AlphaFoldDB; W5M186; -.
DR STRING; 7918.ENSLOCP00000002143; -.
DR Ensembl; ENSLOCT00000002148.1; ENSLOCP00000002143.1; ENSLOCG00000001849.1.
DR GeneID; 102690155; -.
DR KEGG; loc:102690155; -.
DR CTD; 436724; -.
DR eggNOG; KOG1816; Eukaryota.
DR GeneTree; ENSGT00390000002408; -.
DR HOGENOM; CLU_037790_2_0_1; -.
DR InParanoid; W5M186; -.
DR OMA; WMMQQLC; -.
DR OrthoDB; 1125766at2759; -.
DR Proteomes; UP000018468; Linkage group LG20.
DR Bgee; ENSLOCG00000001849; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 2.40.40.50; Ubiquitin fusion degradation protein UFD1, N-terminal domain; 1.
DR InterPro; IPR004854; Ufd1-like.
DR InterPro; IPR042299; Ufd1-like_Nn.
DR PANTHER; PTHR12555; UBIQUITIN FUSION DEGRADATON PROTEIN 1; 1.
DR PANTHER; PTHR12555:SF13; UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1; 1.
DR Pfam; PF03152; UFD1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT REGION 200..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 35118 MW; 01CD539D0602918B CRC64;
MFSFNMFDHP IPRAFQNRFS TQYRCYSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN
ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLMVA
TYSKFQPQSP DFLDITNPKA VLENALRNFA CLTTGDVIAI NYNEKIYELR VMETKPDKAV
SIIECDMNVD FDAPLGYKEP ERRSQHHEEP TEEDADHSSY AEMDVGFRAF TGSGNRLDGK
KKGIEPSPAP LDPNDIKRGI PNYDFRMGKI TFIRNSRPQP KKIDDEDAVN RFIAFSGEGQ
SLRKKGRKP
//
