ID W5M1T5_LEPOC Unreviewed; 1200 AA.
AC W5M1T5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002343.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000002343.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC {ECO:0000256|RuleBase:RU369098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
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DR EMBL; AHAT01034694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M1T5; -.
DR STRING; 7918.ENSLOCP00000002343; -.
DR Ensembl; ENSLOCT00000002348.1; ENSLOCP00000002343.1; ENSLOCG00000002010.1.
DR eggNOG; KOG2162; Eukaryota.
DR GeneTree; ENSGT00940000158333; -.
DR HOGENOM; CLU_009299_0_0_1; -.
DR InParanoid; W5M1T5; -.
DR OMA; WHQAGSA; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000002010; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696:SF5; NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7; 1.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161,
KW ECO:0000256|RuleBase:RU369098}; Nucleus {ECO:0000256|RuleBase:RU369098};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 57..170
FT /note="Telomerase activating protein Est1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10374"
FT DOMAIN 173..429
FT /note="DNA/RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF10373"
FT REGION 507..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1200 AA; 133937 MW; AB4CE877F14F61EF CRC64;
TKLQSSEFCF NRQAEALKAD MTDSKLGPAE VWTSRQALQD LYQKMLVTDL EYALDKKVEQ
DLWNHAFKNQ ITTLQSQAKN RANPNRSEVQ ANLSLFLEAA SGFYTQLLQE LCTVFNVDLP
CRVKSSQLGI ISNKQTSTSA IVKPQPSSCS YICQHCLVHL GDIARYRNQT SQAESYYRHA
AQLVPSNGQP YNQLAILASS KGDHLTTIFY YCRSIAVKFP FPAASTNLQK ALSKALERTD
PFHMMQGTGT AFLSKHTIGY DCSPLTQYQD NLREKLEEQF QRLILQKAFS SQQLVHITVI
NLFELHHLRD FSSESDDHSF SHDEQLSWIQ LLALFMSFLG IMCSRVLLNK NREDLMGECP
LPAIKVSLDW LKLRPSVFHE SAVDERQYIY PSIYGLDHSL HSWMTALRCF PATPLPEEFE
LQGFLALRPA LRTLDFSKGH QGIAVDKEGQ PLRARHQRLI SLGKWVADSQ PRLVQCRIDD
GMLLFVTDIP EPVIEELVEK DGPVLQESSN AEQTSNEGSQ GLKSVLPVGK TQNSSSEGGE
KPVVTFKENI KPRELTRDAN RTHHLKEGLK ERREFSKGNL SSKTDLKKDN KRKNEAKKTC
HEKMQEPGKQ NVAVQVKAQS EIRKTPVSEA RKTPVTQTQT QTSSSSQFIP IHHPGAFPPL
PSRPGFPPPA YVIPPPVAFS MTPGFTFSTG VSVPGAFLQP ATHPQAGSQV QAGKQSHIPY
SQQRPSGPGA LTQGPQQQQG QQQPPTAASQ QAVQPAGQLQ VQGMSQQQQS PTKPVQQQLG
KSPPHHPGLQ QFMQVTEQSS QMWNQHQAQA PLQKNLPIQM SVKQSFYMPP QDPLKLFEQS
LQTVPMQPQQ QPTMDKKMKL FPVEPFGQNA SEVKVQDFYW DPPYRMAADR QMMGQQVNSD
RLVKRPQGSF RSDQDNIPRV SSFEDSKSSP LLPPDLLKSL ADFEEEEELA FTKPHDFYQA
LAGPLNSAPG RSMFLPNQSR LERPSDLMSQ PSLMPLSGFS LQENSYQNSS IFSEAYGKNM
APSTKPEVPS SLAHQEHSLY TLFEGTPWSP SLPASSDHST PASQSPHSSN PSSLPSSPPT
HNHNSIPFSN FGPIGTPDSR DRRIADRWKV EKSAVSGFGL DYLPASSSAS ENSWHQGSTP
CNTWATQESP MEDSSTVLMD SLKSIWSSSM MHPGPSALEQ LLLQQKQKQQ RGHGAMNPPH
//
