UniProt: W5M225

Database: UniProt
Entry: W5M225_LEPOC

LinkDB:  W5M225_LEPOC 
Original site:  W5M225_LEPOC

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Ontology (9)   
   GO (9)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (4)   
   EMBL (4)   
Protein domain (10)   
   InterPro (6)   
   Pfam (1)   
   PROSITE (3)   
All databases (27)   

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ID   W5M225_LEPOC            Unreviewed;       560 AA.
AC   W5M225;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00018388, ECO:0000256|RuleBase:RU000612};
DE            EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002433.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000002433.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC         EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC         ECO:0000256|RuleBase:RU000612};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC       {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC   -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC       ECO:0000256|RuleBase:RU000612}.
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DR   EMBL; AHAT01010636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01010637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01010638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01010639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5M225; -.
DR   STRING; 7918.ENSLOCP00000002433; -.
DR   Ensembl; ENSLOCT00000002438.1; ENSLOCP00000002433.1; ENSLOCG00000002085.1.
DR   eggNOG; KOG2446; Eukaryota.
DR   GeneTree; ENSGT00390000000707; -.
DR   HOGENOM; CLU_017947_3_1_1; -.
DR   InParanoid; W5M225; -.
DR   OMA; MHDVERC; -.
DR   UniPathway; UPA00109; UER00181.
DR   Proteomes; UP000018468; Linkage group LG23.
DR   Bgee; ENSLOCG00000002085; Expressed in muscle tissue and 13 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IBA:GO_Central.
DR   GO; GO:0048029; F:monosaccharide binding; IBA:GO_Central.
DR   GO; GO:0006094; P:gluconeogenesis; IBA:GO_Central.
DR   GO; GO:0051156; P:glucose 6-phosphate metabolic process; IBA:GO_Central.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   CDD; cd05015; SIS_PGI_1; 1.
DR   CDD; cd05016; SIS_PGI_2; 1.
DR   Gene3D; 1.10.1390.10; -; 1.
DR   HAMAP; MF_00473; G6P_isomerase; 1.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR023096; G6P_Isomerase_C.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR035476; SIS_PGI_1.
DR   InterPro; IPR035482; SIS_PGI_2.
DR   PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   Pfam; PF00342; PGI; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU000612};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468}.
SQ   SEQUENCE   560 AA;  62691 MW;  EA83D955FB5267C6 CRC64;
     MAPGLTSDPS FQKLEQWYRA NAGSLNMRQM FEADQGRFGK FSTTLNTDDG DILVDFSKNL
     INEEVMKMLF DLEERSGLGT SGSSVVNHSW INLGQNRAVL HIALRNRSNS PIHVGGKDVM
     PEVNSVLEKM KAFCLKVRSG EWKGYTGKAI TDIVNIGIGG SDLGPLMVTE ALKPYSKGGP
     RAWFVSNIDG THMAKTLAEL NPETTLFIIA SKETSLIPGR VATKRTQPRK RLFLPTFLRD
     QKSAVAKHFV ALSTNAPKVK DFGIDTNNMF EFWDWVGGRY SLWSAIGLSI ALHIGFENFE
     RLLSGAHWMD NHFRTAPLEK NVPVLLALLG VWYINFFQAE THALLPYDQY MHRFAAYFQQ
     GDMESNGKYI TSKGSRVNYH TGPIVWGEPG TNGQHAFYQL IHQGTRMIPC DFLIPVQSQH
     PIRNNLHHKI LLANFLAQTE ALMKGKTTEE ARKELEGAGM SGEPLEKLLP HKVFEGNKPT
     NSIVFKKLTP FMLGALIAMY EHKIFMQGVI WEINSYDQWG VELGKQLAKK IEPELQDAGE
     VTSHDGSTNG LISFIKKNSA
//

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