ID W5M284_LEPOC Unreviewed; 593 AA.
AC W5M284;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=FERM domain containing 3 {ECO:0000313|Ensembl:ENSLOCP00000002492.1};
GN Name=FRMD3 {ECO:0000313|Ensembl:ENSLOCP00000002492.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002492.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000002492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01012659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M284; -.
DR STRING; 7918.ENSLOCP00000002492; -.
DR Ensembl; ENSLOCT00000002498.1; ENSLOCP00000002492.1; ENSLOCG00000002132.1.
DR eggNOG; KOG3530; Eukaryota.
DR GeneTree; ENSGT00940000158577; -.
DR HOGENOM; CLU_003623_1_7_1; -.
DR InParanoid; W5M284; -.
DR OMA; CPLRQWM; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000002132; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17102; FERM_F1_FRMD3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF8; FERM DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 524..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..296
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 402..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 67602 MW; 58DC4F4B74C21661 CRC64;
MLRFRTSSVK SLNQEIKCTI RLLDDSEISC NIQRDTKGQF LLDHVCNHYS LLEKDYFGIR
YVDPEKQRHW LEPNKCIVKQ MKSHSPYTMC FRVKFYPHEP MKIKEELTRY LLYLQLKRDI
FHGRLLCSFS DAAYLGACII QAELGDYDSD EHPEDYVSEF KMFPKQTLKL EKKIAEIHKS
ELRGQCPAIA ELNLLQRAHT LETYGVDPHP CKDFTGSTAF LGFTATGFVV FQGNKRIHLL
KWTDVSKLKF EGKTFYVIGI QKEKKLVLTF HTSTPAACKH LWKCGVENQA FYKCAKSSQI
KTVSSSNIFF KGSRFRYSGR VAKEVIEASS KIQRDPPEVH RSAIGQSKSF NSLNNKQLIM
NVEPLLPALP SSNEHEESAS ENGLLALKDV VHLSPMKSSL LEVDPGDLNE CRASGEKPAE
DLPSEDNPGG DEEALTISEL MYNPCTSVLP TPVEDGGIDL LFDHPVKLAK EPDVDNESYE
ELEADERAFL IAEEEEMKEV RRVLGCSYKL LTGNKQLNAC MQSFVRLLAV GLGLLVFALP
LLLVLLESDI DISFLHEIRQ TPEFEQFHHE YYCPLRQWMT CKMNFILDKL GGS
//
