ID W5M3V0_LEPOC Unreviewed; 455 AA.
AC W5M3V0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Fli-1 proto-oncogene, ETS transcription factor {ECO:0000313|Ensembl:ENSLOCP00000003058.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003058.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000003058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; AHAT01024125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01024126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M3V0; -.
DR STRING; 7918.ENSLOCP00000003058; -.
DR Ensembl; ENSLOCT00000003064.1; ENSLOCP00000003058.1; ENSLOCG00000002563.1.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000158261; -.
DR InParanoid; W5M3V0; -.
DR OMA; AXSLLAY; -.
DR Proteomes; UP000018468; Linkage group LG26.
DR Bgee; ENSLOCG00000002563; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd08541; SAM_PNT-FLI-1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR035573; SAM_PNT-FLI-1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF161; FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 117..203
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 284..364
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 204..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 51077 MW; 0E1AB4B5C2C8F053 CRC64;
LFSSIEMICK VLSDEALSVV SDDQSLFEPP YAAVPLPKPD MTASGTQDYG PPHKINPLTP
QQDWINRVNV KREYDHLNGS SRESPVDCSV GKCGKLVGGA EATQINYGSY MDEKNGPPPP
NMTTNERRVI VPADPSLWSQ DHVRQWLEWA IKEYGLLEID TSLFQSTDGK ELCKMSKEDF
LRLTSVYNAE VLLSHLNYLR ESSSSLSYNT PHTDQSPRLT TKEDPSYDSA RRTGWSNSMH
SGKGSPAVTQ NVSKTSEQQR PQPDPYQILG PTSSRLANPG SGQIQLWQFL LELLSDSANA
GCITWEGTNG EFKMTDPDEV ARRWGERKSK PNMNYDKLSR ALRYYYDKNI MTKVHGKRYA
YKFDFHGIAQ ALQPHPTESS MYKYPSDLAY VPSYHAHQQK VNFVSPHPPS MPVTSSNFFG
PPSPYWSSPA GGIYPNPSVP RHPNTHVSSH LGSYY
//
