ID W5M4F4_LEPOC Unreviewed; 164 AA.
AC W5M4F4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Insulin-like 3 {ECO:0000256|ARBA:ARBA00014427};
DE AltName: Full=Leydig insulin-like peptide {ECO:0000256|ARBA:ARBA00032881};
DE AltName: Full=Relaxin-like factor {ECO:0000256|ARBA:ARBA00032209};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003262.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000003262.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Seems to play a role in testicular function. May be a trophic
CC hormone with a role in testicular descent in fetal life. Is a ligand
CC for LGR8 receptor. {ECO:0000256|ARBA:ARBA00025288}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; AHAT01011201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006640027.1; XM_006639964.2.
DR AlphaFoldDB; W5M4F4; -.
DR STRING; 7918.ENSLOCP00000003262; -.
DR Ensembl; ENSLOCT00000003269.1; ENSLOCP00000003262.1; ENSLOCG00000002776.1.
DR GeneID; 102687514; -.
DR KEGG; loc:102687514; -.
DR CTD; 3640; -.
DR eggNOG; ENOG502S7EX; Eukaryota.
DR GeneTree; ENSGT00940000174859; -.
DR HOGENOM; CLU_120043_0_0_1; -.
DR InParanoid; W5M4F4; -.
DR OMA; QERIKIC; -.
DR OrthoDB; 5360690at2759; -.
DR Proteomes; UP000018468; Linkage group LG19.
DR Bgee; ENSLOCG00000002776; Expressed in bone element and 3 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00101; IlGF_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR043387; INSL3/INSL4.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR10423; INSULIN-LIKE 3; 1.
DR PANTHER; PTHR10423:SF3; INSULIN-LIKE 3; 1.
DR Pfam; PF00049; Insulin; 1.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|RuleBase:RU000406}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..164
FT /note="Insulin-like 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004865638"
FT DOMAIN 26..164
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 74..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 164 AA; 18234 MW; 703CEB7B30F466B0 CRC64;
MPRWFSSFLF LLVVWHSGAR TQDNRVKLCG REFIRMVVTS CGSSRLKRST PESDQPRVNP
YWKLLERLTS DELNDWEDPG TSVTTVTWSS PAGDLAGEPG PLPPRERTSS MSRVPRESRA
EGDPSVPAQT FLPLTGSSRS RREVGPAGVC CRSGCTLSEL VQYC
//
