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Database: UniProt
Entry: W5M4R4_LEPOC
LinkDB: W5M4R4_LEPOC
Original site: W5M4R4_LEPOC 
ID   W5M4R4_LEPOC            Unreviewed;      1762 AA.
AC   W5M4R4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   20-JUN-2018, entry version 34.
DE   SubName: Full=Sodium leak channel, non-selective {ECO:0000313|Ensembl:ENSLOCP00000003372};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003372, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000003372, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000003372}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AHAT01025041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01025042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01025043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01025044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015218940.1; XM_015363454.1.
DR   RefSeq; XP_015218941.1; XM_015363455.1.
DR   Ensembl; ENSLOCT00000003379; ENSLOCP00000003372; ENSLOCG00000002812.
DR   GeneID; 102695809; -.
DR   CTD; 259232; -.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; CQRIVGP; -.
DR   OrthoDB; EOG091G00F9; -.
DR   Proteomes; UP000018468; Linkage group LG17.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1762       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004865649.
FT   TRANSMEM    133    152       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    164    183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    203    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    409    430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    442    470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    530    552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    599    623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    905    929       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    941    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    980    998       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1041   1064       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1261   1280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1300   1318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1360   1382       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1447   1471       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       61    355       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      408    627       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      911   1186       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1233   1481       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      822    851       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1762 AA;  203078 MW;  19D6B6A95433E9E4 CRC64;
     MCRAGAISAL LLPLIHSLYS TTSPSMLKRK QSSRVEAQPM TDFGPDETLA DNADILWINK
     PWVHSLLRAC AIISVISVCM NTPKTFEHYP PLQYVTFALD TLLMFLYTAE MIAKMHIRGI
     VKGDNSYVKD RWCVFDGIMV FCLWVSLVLQ VFEIAELVDQ MSPWGMLRIP RALIMIRAFR
     IYFRFELPRT RITNILKRSG EQIWSVSIFL LFFLLLYGIL GVQMFGTFTY HCVTNDTQPG
     NVTWNNLAIP DTHCSPDGEG YQCPMGFKCM DLEDLGLSRQ ELGYSGFNEI GTSIFTVYEA
     ASQEGWVFLM YRAIDSFPRW RSYFYFITLI FFLAWLVKNV FIAVIIETFA EIRVQFQQMW
     GSRSSTTSTA TTQMFHEDSA GGWQLVAVDV NKPHGRAPAC LQKMMRSSVF HMFILSMVAV
     DVIVAASNYY KGENHRRYYD EFYLAEVAFT VLFDLEALLK IWCLGFTGYI SSSLHKFESL
     LVVGTTLHIY PDLYHSQFTY FQVLRVVRLI KISPALEDFV YKIFGPGKKL GSLVVFTASL
     LIVMSAISLQ MFCFVEELDR FTTFPRAFMS MFQILTQEGW VDVMDQTLVA VGHMWAPVVA
     IYFILYHLFA TLILLSLFVA VILDNLELDE DLKKLKQLKQ SEANADTKEK LPLRLRIFEK
     FPNRPQMVKI SKLPSDFTVP RIRESFMKQF IDRQQQDTSC LLRRLPSASS SSCDHSKRSG
     IEDNKYIDQK LRKSISSIRA RNLLEKETTI NKTLRACTRQ RMLSGSFEGQ PAKERSILSV
     QHHIRQERRS LRHGSNSQRI SRGKSLETLT QDHSSTVRYR NAQREDSEIK MIQEKKEQAE
     MKRKVQEEEL RENHPYFDKP LFIVGREHRF RNFCRVIVRA RFNASKTDPI TGAVKNTKYH
     QLYDLFGLVT YLDWVMIVVT ICSCISMMFE SPFTRVMHVP TLQIAEYVFV IFMSIELNLK
     IMADGLFFTP TAVIRDFGGV MDIFIYLVSL IFLCWMPANV PPESGAQLLM MLRCLRPLRI
     FKLVPQMRKV VRELFSGFKE IFLVSILLLT LMLVFASFGV QLFAGKLAKC NDPRITRRED
     CYGIFRINVS VSKNLNLKLR PGERKPGFWV PRVWANPRNF NFDNVGNAML ALFEVLSLKG
     WVEVRDVIIH RVGPIHGIYI HVFVFLGCMI GLTLFVGVVI ANFNENKGTA LLTVDQRRWE
     DLKSRLKIAQ PLHLPPRPDN DGFRAKMYDI TQHPFFKRTI AVLVLAQSVL LSVKWDVDDP
     VTVPLATMSV VFTFIFVLEV TMKLIAMSPA GFWQSRRNRY DLLVTSLGVI WVILHFALLN
     EYTYMMGACI IVFRFFSICG KHVTLKMLLL TVVVSMYKSF FIIVGMFLLL LCYAFAGVVL
     FGTVKYGENI NRHANFSTAG KAITVLFRIV TGEDWNKIMH DCMVQPPFCT PDKHRYWETD
     CGNYAGALIY FCSFYVIIAY IMLNLLVAII VENFSLFYST EEDQLLSYND LRHFQIIWNM
     VDDKREGVIP TSRVKFLLRL LRGRLEVDLD KDKLLFKHMC YEMERLHNGG DVTFHDVLSM
     LSYRSVDIRK SLQLEELLAR EQLEYTIEEE VAKQTIRMWL KKCLKRIRAK QQQSCSIIHS
     LRESQQQELS RFLNPPSIET TLPSEDANAN NQDNPSQPET SSQQQLLSPT LSDRGGYRQD
     STELGKPQRK FGQWRLPAAP KPISHSVSSV NLRFGGRTSM KSIVCKANPM NEETSSGSEV
     KKWWTRQLTV ESDESGDDLI DI
//
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