ID W5M5I9_LEPOC Unreviewed; 887 AA.
AC W5M5I9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|PIRNR:PIRNR001569};
DE EC=2.3.2.26 {ECO:0000256|PIRNR:PIRNR001569};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003647.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000003647.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885,
CC ECO:0000256|PIRNR:PIRNR001569};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906, ECO:0000256|PIRNR:PIRNR001569}.
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DR EMBL; AHAT01010575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01010576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01010577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01010578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01010579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M5I9; -.
DR STRING; 7918.ENSLOCP00000003647; -.
DR Ensembl; ENSLOCT00000003654.1; ENSLOCP00000003647.1; ENSLOCG00000003079.1.
DR eggNOG; KOG0940; Eukaryota.
DR GeneTree; ENSGT00940000160726; -.
DR HOGENOM; CLU_002173_0_1_1; -.
DR InParanoid; W5M5I9; -.
DR OMA; EIDMADW; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000018468; Linkage group LG23.
DR Bgee; ENSLOCG00000003079; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IBA:GO_Central.
DR CDD; cd04021; C2_E3_ubiquitin_ligase; 1.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd00201; WW; 4.
DR Gene3D; 2.20.70.10; -; 3.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR024928; E3_ub_ligase_SMURF1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF396; NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00397; WW; 4.
DR PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00456; WW; 4.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF51045; WW domain; 4.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 4.
DR PROSITE; PS50020; WW_DOMAIN_2; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001569};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PIRNR:PIRNR001569}.
FT DOMAIN 1..121
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 314..347
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 344..377
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 420..453
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 460..493
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 553..887
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 855
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001569-1,
FT ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 887 AA; 100411 MW; DA1577C59DCA8DDA CRC64;
MASASSSRSG VGQSSEKSQL TLKVLSAKPQ SPKSPSRHSR LNSFVEVTAD GLSSETKKTG
KRCGHPELQW NEDLTLNVTP QSHLDLKLWS CHALRNELLG IASIDVYDTL KSNNGKMENV
QLNLALQTEN KGSLVPGGEL TVCLDGLAVD LGSLPNGSAV TDKPQQSDGH GIRRTQSEDS
PPSSSGSCSG PRGRSHRHSA GMARGGPVAN GDPAVNGEHS PGARSRRRQT GKALSSNTGL
GTPGKAEVAA NGTEDGRRSP TCQTPPPSAA LSTSTTPCAG TPSSGSDAPQ GDTGETGGTP
TPDQASAAPE QNMESLPPGW EQRVLPNGRI YYVDHNTKTT TWERPLPPGW EKRVDQRGRF
YYVDHNTRTT TWQRPTAESV RNYEQWQSQR SQLQGAMQQF SQRFLYQSIG MRALQRTKLS
LLNSGWYEKR QDNGRVYFVN HNTRTTQWED PRTQGMIQEP PLPPGWEMKY TNEGVRYFVD
HNSRTTTFKD PRPGFDSGSK QGGSPGAYDR SFRWKYHQFR FLCHSNALPS HVKISVSRQT
LFEDSFQQIM NMKPYDLRRR LYIIMRGEEG LDYGGIAREW FFLLSHEVLN PMYCLFEYAG
KNNYCLQINP ASSINPDHLT YFRFIGRFIA MALYHGKFID TGFTLPFYKR MLNKKPTLKD
LESIDPEFHN SIMWVKENNL EECGVELYFA QDMEILGKVS THELKTDGEN ELVTEDNKEE
YIRLLTDWRF TRGVEEQTKA FLDGFNEVVP LEWLRYFDEK ELELMLCGMQ EIDLTDWQKN
TIYRHYTKNS KQIQWFWQVV KEMDNEKRIR LLQFVTGTCR LPVGGFSELI GSNGPQKFCI
DKVGKETWLP RSHTCFNRLD LPPYKSFEQL KEKLLFAIEE TEGFGQE
//