ID W5M5P3_LEPOC Unreviewed; 694 AA.
AC W5M5P3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Staufen double-stranded RNA binding protein 1 {ECO:0000313|Ensembl:ENSLOCP00000003701.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003701.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000003701.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01025290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M5P3; -.
DR STRING; 7918.ENSLOCP00000003701; -.
DR Ensembl; ENSLOCT00000003708.1; ENSLOCP00000003701.1; ENSLOCG00000003134.1.
DR eggNOG; KOG3732; Eukaryota.
DR GeneTree; ENSGT00940000157304; -.
DR InParanoid; W5M5P3; -.
DR OMA; YTFRQAP; -.
DR Proteomes; UP000018468; Linkage group LG18.
DR Bgee; ENSLOCG00000003134; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR GO; GO:0032839; C:dendrite cytoplasm; IEA:GOC.
DR GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0098964; P:anterograde dendritic transport of messenger ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0008298; P:intracellular mRNA localization; IBA:GO_Central.
DR GO; GO:0035418; P:protein localization to synapse; IBA:GO_Central.
DR CDD; cd19879; DSRM_STAU1_rpt1; 1.
DR CDD; cd19887; DSRM_STAU1_rpt5; 1.
DR Gene3D; 3.30.160.20; -; 5.
DR Gene3D; 6.10.250.1360; -; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR032478; Staufen_C.
DR PANTHER; PTHR46054:SF2; DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1; 1.
DR PANTHER; PTHR46054; MATERNAL EFFECT PROTEIN STAUFEN; 1.
DR Pfam; PF00035; dsrm; 4.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 4.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 4.
DR PROSITE; PS50137; DS_RBD; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 80..147
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 166..257
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 279..346
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 381..449
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 694 AA; 75605 MW; 311F4A441E46D5F7 CRC64;
DVSMAQVQVQ SPAGSPLSNT TQHLKPSAPQ PNLSIPNASG PLPSENASHP LKNSALPSAS
ATPISAPAAF SNMANPKEKT PMCLVNELAR FNKIQPEYKL LSEQGPAHSK LFSVRLTLGE
QHWEAEGTSI KKAQHAAAAS ALSQTTLPKP TIRPPRSTGK NPDSITHTVE LNALCMKLGK
KPIYKPIDPY PGMRPNFNYN VRPPGPYPRY YYPFPPVGPV MYHMELSIGG QQFHGKGRTR
QAAKHDAAAK ALKVLQKEPL LEKRLEVNGE QSEENLNKSE ISQVFEIALK RNMPVNFEVV
KETGPPHMKS FVIKVTVGEF SGEGDGKSKK IAKKNAATAV LEELKKLPPL PTVEKVQPRI
KKKTKSIVKL QTSPEYGQGM NPISRLAQIQ QAKKEKEPEY SLVTERGLPR RREFVMQVKV
GNQCSEGMGP SKKVAKRNAA EKMLELMGFK VPQPQPPKPA LKSDEKVQAK KAGEGRKVTF
FEPSVVEDAG IGSREDEFRM PFLSHQQLPA GILPMVPEVA QAVGASQGHH AKDYNRSPIN
PAKATVTAMI ARELLYGGTS PTAETILKGS SSLGHLPHGP LTRPSEQLDY LSTVQGLQVE
YKDFPKNNKN EFVSLINCSS QPPLISHGIG KDVESCHDMA ALNILKLLSE LDQQSNDRTG
NGPISVCGKQ EMEGDALLKQ ANSNTMGQTL DGTA
//
