ID W5M6Y0_LEPOC Unreviewed; 418 AA.
AC W5M6Y0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 {ECO:0000313|Ensembl:ENSLOCP00000004138.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000004138.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000004138.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; AHAT01018539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01018540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015199814.1; XM_015344328.1.
DR AlphaFoldDB; W5M6Y0; -.
DR STRING; 7918.ENSLOCP00000004138; -.
DR Ensembl; ENSLOCT00000004146.1; ENSLOCP00000004138.1; ENSLOCG00000003489.1.
DR GeneID; 102685110; -.
DR CTD; 50859; -.
DR eggNOG; KOG3555; Eukaryota.
DR GeneTree; ENSGT00940000157828; -.
DR HOGENOM; CLU_037217_1_0_1; -.
DR InParanoid; W5M6Y0; -.
DR OMA; PQTAVCI; -.
DR OrthoDB; 4174283at2759; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000003489; Expressed in camera-type eye and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd16239; EFh_SPARC_TICN3; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR PANTHER; PTHR13866:SF21; TESTICAN-3; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Heparan sulfate {ECO:0000256|ARBA:ARBA00023207};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..418
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004865642"
FT DOMAIN 120..171
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 264..299
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 298..364
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 396..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 336..343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 418 AA; 47038 MW; 22923CAAC425A6AB CRC64;
MLSTALLCIC AVACSQVVGA AARSDTANFL DDKWLTGRWD KFRDEPGTWN PGKPFDQAST
ILWSDVHILS HQALDPTRDP CLKVKCSRHK VCVAQDYQTA NCVSQRRMTH SMKEGVLTQK
PGSSKCKQCS FVHPSPVCGT DGHTYSTKCK LEYQACISGK QISMKCPGYC PCLSNKSKNK
VEKKTCSDME LREVVSRLRD WFKVLHENGS QNKKVKIQRP ERSRFDTSIL PICKDSLGWM
FNRLDTNFDL LLDQSELASL YLDKNEHCTK SFFNSCDTYR DGLISNNEWC SCFQRQQDPP
CQTELSSIQR QQAGKKFLGL YIPSCDEDGY YTSTQCHGSI GQCWCVDRYG NEIVGSRTHG
PLDCGVDVDA SGDFGSGHFH ELSDDEDGEV DILNDEDEIV DDDEDEGDDE DDEEGYIS
//
