ID W5M786_LEPOC Unreviewed; 1697 AA.
AC W5M786;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma, 3b {ECO:0000313|Ensembl:ENSLOCP00000004244.1};
GN Name=EIF4G3 {ECO:0000313|Ensembl:ENSLOCP00000004244.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000004244.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000004244.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR EMBL; AHAT01009727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01009728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01009729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000004252.1; ENSLOCP00000004244.1; ENSLOCG00000003549.1.
DR GeneTree; ENSGT00940000156454; -.
DR HOGENOM; CLU_001519_2_0_1; -.
DR Proteomes; UP000018468; Linkage group LG25.
DR Bgee; ENSLOCG00000003549; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF23; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 1333..1455
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1528..1697
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..62
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1697 AA; 185919 MW; B95D0B593A4917AC CRC64;
MSLPPKAVPK SAAAAGSGPG TGPSPPSQLR ALPTSVALPG APAAPQPPAA PPPPPPPQIS
RVQPPLEDRI FPGQPGVTAV YSVPRPPGPP YSTHEITKGH PNLAATPPGH ASSPGLSQSP
YTSGQNAGTT PLVYPPPTQP MNAQPQTRPF ATGPRPTHHQ GGFRPIQFFQ RTQMQTARAT
IPSNNPSIRP GSQTPTAAVY PPNQPIMMAM TPMPFPSPQT AQYYIPQYRH STPYVGPPQQ
YSVQPPGPNT FYPGPGPGEF PTPYAPPYYT GQTVYTPSPP IIVPTPQQPP PAKREKKTIR
IRDPNQGGKD ITEEIMSGGG GSRNPTPPVG RPSSTPTPPQ LSNQVPDHGH MLYSVENPQL
IAAAVDIKPD DKPKLDITAL KSSSPGLRLP DTLADKKEPS GPAQDSSPPE KLELPTSSPA
VVPGPVTATS VPIAGSCKPV LLGERAEPPA PKEEPKPACS VSPQPESSDF ERAMPELPRS
LSTSPAPAVK EMNGLSEKEA ASPCSDSDSQ SRELASPSQS QPAASNSSAD AQEVVSREVR
AESPQTNLAA VAPAAAASPS FITTAAITTA AAAAPPPPGL LVASQGTAES GEARRITVGS
EVKENPPKAG AGAEVTQDEK PNSLPQAGSR KGPSTAHAAP TAPKTWKKPK EGTPVGEVPE
KESEPEPREE LSAERAPDPE LERCSPVPPE GEKKPPVPEE NGEQEPEPVR NGGEHISETE
SSDSGVAPGE KEGSTEPMET EGKKQYDREF LLGFQFMPAC VQKPEGLPPI SDVVLDKINQ
NKLPMRTLDT RVISRGPDFT PAFADFGRQI SGGRGAALLN AGPRRPQPRK IIMNVSVNDE
VQLKKAEHAW KPTLKREGPS EDPEAQKTKE LFRKVRSILN KLTPQMFNQL MKQVTELTID
TEERLKGVID LVFEKAIDEP SFSVAYANMC RCLATLKVQM ADKPNSTVNF RKLLLNRCQK
EFERDKVDDD VFERKQKELE SASSSTEREQ LQEELEEAKD KARRRSIGNI KFIGELFKLK
MLTEAIMHDC VVKLLKNHDE ESLECLCRLL TTIGKDLDFE KAKPRMDQYF NQMEKIVKER
KTSSRIRFML QDVIDLRLNI WVSRRADQGP KTIEQIHKEA KIEEQEEQRK VHQQLLSKDK
RRPVMQREET WNTVPVTKNS RTIDPSKIPK ISKPTIDDKI QLGPRAQLSW VKGSSGGAKS
SDSDSSRSST TSLNRFSPLQ SSLPAATVSP AVTSDYESRR SLSGRGSAGR ERNDKPMPAA
PSRTGPFTRG GSSKDLLDSQ AQEEQRHDML ETVKQLTVAE EKPEAESSRA RDTGKSETPA
ALTADKPTMT EEEMERKSKS IIDEFLHIND YKEAVQCVEE LDQLALLHVF VRVGVESTLE
RSQITRDHMG QLFFQLVQSG TLSKQEFFKG FADTLELADD MAIDIPHIWL YLAELVNPMF
RDGGISMREL FTEFSKPLLP VGRAGILFSE ILHLLCKQMS HRKVGALWRE SGLNWVDFLP
EGEDVHNFIS DLKLEFTISD CSSPTEALSK RELSPDELNK QLEKLLLEDM ASDEQIFDWV
EANLDESQMS SPPFLRALMT AVCKAAVKGE STACRVDTAI IQRRLPVLLK YLNSDTERQL
QALYALQALI VKLDQPPNLL RMFFDCLYDE DVISEDAFYK WESSKDPAEQ LGKGVALKSV
TAFFTWLREA EEESEDN
//
