ID W5M9P3_LEPOC Unreviewed; 2398 AA.
AC W5M9P3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Senataxin {ECO:0000313|Ensembl:ENSLOCP00000005102.1};
GN Name=SETX {ECO:0000313|Ensembl:ENSLOCP00000005102.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005102.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000005102.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01025377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000005102; -.
DR Ensembl; ENSLOCT00000005110.1; ENSLOCP00000005102.1; ENSLOCG00000004264.1.
DR eggNOG; KOG1801; Eukaryota.
DR GeneTree; ENSGT00940000160918; -.
DR HOGENOM; CLU_000967_0_0_1; -.
DR InParanoid; W5M9P3; -.
DR OMA; HTMEREA; -.
DR Proteomes; UP000018468; Linkage group LG21.
DR Bgee; ENSLOCG00000004264; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0001147; F:transcription termination site sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR CDD; cd18042; DEXXQc_SETX; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 1788..2071
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 2078..2278
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 749..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2327..2398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1937..1982
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 840..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1467..1490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1535
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2333..2387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2398 AA; 270650 MW; 7F0DF2A342A27646 CRC64;
MSTCRWCTPG GSEATELLKK YSSRSLSPEE ENALNEDLCY CLECVVEYHR ARDELPSFHK
LLWNLETSRL LDRFTQSCDA ELEEDDLFIV EDDQEIYVPK FTGPEYENFL RVPLLEILKY
PYLLEHREIS EMCVETLCKM EKVNSFQVFD KYPGIYLLLV HPNETVRKWA ICTARSLGKV
DRDDFYDLQE VFSCMCRAIE LDLILNSDLF SSYVRKEGKM VLLPPHLYDC SNYKNYWLGI
CMLLTVLDAQ AMDSLLLGPD KQNDLMQSIL NAMEKEEEDE KLDPFWPALQ CFMVILDRLG
SKVWGKLIDP ARAFQRITRS RSYQKELENL RQTTNGTKVE LEDAMTTCSQ IIYDCNKEKS
KQDSGTKTAV NAENCAHLYE EMHSLMNVLQ SDMGKEMRVH NSTFLWLISF VQSVVDLKEL
SIVCIGEIVH FLCGEINNFI NGQIQKCDKV TEFFILVLVF VIELHLNKSS MNILNYSSSI
WVDVIVNCAV LSVSAFSASS DSCTARKSST SSLRTLSWHP QVSNVVPQAC VQIIRSLLKE
GCKLSVERPS KYFLDLLNKH LRETAYREWR LSSSQLKNLQ LCLRQLVANL NGKEESPGSG
TNSGDDMKYP IASIKQERVE EWDGCENQDN GMTSTSNTCE RNTGLGVLHQ NYPLKQEVPW
DGEDCGQLAS GIHPNVGDRS FKTDLQDQYQ LPLKKERTSP VHMCSDSNKS KISYSFKSEM
PDSVRSDDLK SEQNNGPLCK ISEVISCPSS ANDQKDDVSF VSKKNEGGQK LSNEECASGS
KRPLECISKY EASSGGPHIS NVKYGKSESS DDDDDDVPLT VIMSNLHKTT SLYKTLKNSM
QLTDPQTDRD VNLQSSTASS ESTSFPSNSN KEYSVSRDRI ERRVKCNARS GQALENQDVV
ILEPDTDSGA VIVISDSESA KDDNETPHAN SKETCRNFKA QEMTIKCEHS KSIDLMNDVS
KSANNGGTDC GFNEYDSQLF EFETEEKVFS AWEDPEISTV VGDTENKDAS NELPFLHSSE
DLNDLCNDWG YETDFIPDDY IHKASEYAEE LIKKQQISED CIEKDPEKEP TTSSFNNDTK
EPPCRIAGEN DDQSPISLLK KTLSKKLAEK RASSGASISN VTKDLGTYSK KGTNGRSLKK
PKETSSSSKN NFKKATTTLP LKVTEPAIIT PKKVRQQPEP NSTAEKLGLK KRERKAFDLS
QRSLDCVAQL RNYGQRFRIE NETRKYRTTK SSLPSRQKQI PKNKRKMLAS QDLQYFRLSR
AITQKKSSGL IDSLKAKENK QLAKEEKDVI SPKASAAKTG CSDGDAGGNK LFFLSSLPIP
QVAESDQLER NCDLTSKEIP EVSSTTCSAN ELGVFAQLNT DLPQEVAGQP RKHEFKNMYL
TQMDPVDMEL CPELDNADNF ALTQRDPVDM EIDENDSGKV DSIREGQVAH SSWADTYASG
SVEKSVTSEQ KDDHVFLKPG IPSPYLKQAK PSTTKIYAQS SRNANLAQEM EKTSKPLPAA
LKIRAVRPPP PLRRSSMPPP ESRSPLQPKT PVTPSSNPPE SRIVAYKPRV PVCTPHERTD
SSTTKKPPHS ASSFRFNQND MIQQMLKWNL REVPTNFTSF EDYFTTFYPL LMVNAFEELV
NNWRQSKSTI RNSLRPVAVE YPNGVSNATF TASLTRSEVD RQLYPKEEHL VCLWLHQHTN
TYANEDSEML EPIPSIGYVL RANISHGGDT PTLTLTIQTR VSFSLQKLPV MCEVIGSLIS
TIRGFKGLSM LRNSLMARPL LSPNAAYFSF GEQKNVCHMP LSAVQREFNT DQVKAINCAL
TMIKEQRRTP KICLIQGPPG TGKTRTIVGL LQRIFTEDRE NLMPQGNRIF KGRKPRVLVC
APSNAAVDHL MRNIIVDFKG KCRNRQTPLG NCGDINLVRL GMEKAISDKL LGFSLDHQIK
VKTKKGQEHD TGIHRRKEQL DQELERVSNL LSSVNKKDIL KLQRLTDEKF KLLEERKQLG
RMLRETKVKK QEIQTKIVLD AHVICCTLNT SGSILLESAF RRLGHDPFCC VIVDEAGQAT
ETETLIPLMH RCPCLVLVGD PEQLPPTVVS QKAKEKGYDQ SLMARLWKSL HRELRAKPHV
PNPIIFLATQ YRMHPDICEF PSRYIYDRAL KTDGETAEKR CGISWPFQPY ILFDVTDGFE
TRNEDSFSNL QEVKLVIRLI KLIFEKQVTR VGVITPYSAQ KQKIKEYINK EQKLDTNKHF
QSVEVDTIDG FQGCEKDCII VSCVRACSTQ GSIGFMGNRQ RLNVTITRAK FSLFILGHLR
TLTEHKDWEA LIQDAGKRGT IIKTREKDYN ADARKIFKPE PGFLRSFSFP PKDSSLLPKT
STPTDNRRMS ADKSSMVKNS ALPAARTTAT VSRSQTSDSS TGKPSTSGRP RDPRLASR
//
