ID W5MA24_LEPOC Unreviewed; 198 AA.
AC W5MA24;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Receptor activity-modifying protein 1 {ECO:0000256|ARBA:ARBA00041071};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005233.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000005233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transports the calcitonin gene-related peptide type 1
CC receptor (CALCRL) to the plasma membrane. Acts as a receptor for
CC calcitonin-gene-related peptide (CGRP) together with CALCRL.
CC {ECO:0000256|ARBA:ARBA00037503}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP1.
CC {ECO:0000256|ARBA:ARBA00038839}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the RAMP family.
CC {ECO:0000256|ARBA:ARBA00007087}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01011357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MA24; -.
DR STRING; 7918.ENSLOCP00000005233; -.
DR Ensembl; ENSLOCT00000005241.1; ENSLOCP00000005233.1; ENSLOCG00000004383.1.
DR eggNOG; ENOG502S0TC; Eukaryota.
DR GeneTree; ENSGT00940000159224; -.
DR HOGENOM; CLU_116349_3_0_1; -.
DR InParanoid; W5MA24; -.
DR Proteomes; UP000018468; Linkage group LG12.
DR Bgee; ENSLOCG00000004383; Expressed in muscle tissue and 11 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0015026; F:coreceptor activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0031623; P:receptor internalization; IBA:GO_Central.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.150.510; Receptor activity modifying family; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP; 1.
DR PANTHER; PTHR14076:SF3; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; 1.
DR Pfam; PF04901; RAMP; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 198 AA; 22434 MW; 0D85B7A409EAA727 CRC64;
MALDYAPVTS RPVLVWFVIA HHFISVTACD EAFYVHAIEE HCLAKFTFDM EALDPGYWCN
WEDTVERALL MSGLQSAQGQ QPCVMTLFCK QTPLTLARAD MGGHLSLIAE RRTRSYGELT
NCTYLIAQKM NCFWPNRLVD EFFIGIHRLY FKNCSLSGRL PSDPPNNILG PFIAVPILVT
LLMTALVVWR SKRSEGIV
//