ID W5MA74_LEPOC Unreviewed; 356 AA.
AC W5MA74;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Erlin-1 {ECO:0000256|ARBA:ARBA00040567};
DE AltName: Full=Endoplasmic reticulum lipid raft-associated protein 1 {ECO:0000256|ARBA:ARBA00041391};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005283.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000005283.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family.
CC {ECO:0000256|ARBA:ARBA00008164}.
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DR EMBL; AHAT01025209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MA74; -.
DR STRING; 7918.ENSLOCP00000005283; -.
DR Ensembl; ENSLOCT00000005291.1; ENSLOCP00000005283.1; ENSLOCG00000004418.1.
DR eggNOG; KOG2962; Eukaryota.
DR GeneTree; ENSGT00390000014666; -.
DR HOGENOM; CLU_058701_0_0_1; -.
DR InParanoid; W5MA74; -.
DR OMA; CAFQQAN; -.
DR Proteomes; UP000018468; Linkage group LG5.
DR Bgee; ENSLOCG00000004418; Expressed in larva and 13 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0032933; P:SREBP signaling pathway; IBA:GO_Central.
DR CDD; cd03406; SPFH_like_u3; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR033294; Erlin1/2.
DR PANTHER; PTHR15351; ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG; 1.
DR PANTHER; PTHR15351:SF2; ERLIN-1; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..356
FT /note="Erlin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867831"
FT DOMAIN 23..190
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT REGION 310..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 40021 MW; 2A2AAEE29B7FB6FC CRC64;
MAMAHVGAVV AAVTGVLAVL LHSSIHKIEE GHLAVYYRGG ALLTVPNGPG YHIMLPFITT
FRSVQTTLQT DEIKNVPCGT SSGGVMIYFD RIEVVNMLVP SAAVDIVRNY TADYDKTLIF
NKIHHELNQF CSVHTLQEVY IELFDIIDEN LKLSLQKELN VMAPGLTIQA VRVTKPKIPE
AIRRNFELME AEKTRLLITA QTQKVVEKEA ETERKKAIIE AQKVAQVAEI HFRQKVMEKE
TEKKISEIED AAFLARERTR ADAEYYTAAK FAEANRMKLT PEYLELMKYQ AIAANSKIYF
GQDIPNMFME NSGSQARTQD EEEEGSPDLL DSLGKTRKHK KAPRSSTRDS KSGSPE
//
