ID W5MBS5_LEPOC Unreviewed; 1095 AA.
AC W5MBS5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Bromodomain testis associated {ECO:0000313|Ensembl:ENSLOCP00000005834.1};
GN Name=BRDT {ECO:0000313|Ensembl:ENSLOCP00000005834.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005834.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000005834.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01018345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01018346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01018347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MBS5; -.
DR STRING; 7918.ENSLOCP00000005834; -.
DR Ensembl; ENSLOCT00000005842.1; ENSLOCP00000005834.1; ENSLOCG00000004853.1.
DR eggNOG; KOG1474; Eukaryota.
DR GeneTree; ENSGT00940000154549; -.
DR HOGENOM; CLU_001499_0_1_1; -.
DR InParanoid; W5MBS5; -.
DR OMA; IKAREPT; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000004853; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070577; F:lysine-acetylated histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR031354; BRD4_CDT.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF238; BROMODOMAIN TESTIS-SPECIFIC PROTEIN; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF17105; BRD4_CDT; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..117
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 281..353
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 503..585
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..457
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..842
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1075
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 122338 MW; F095D33A75A3C4DB CRC64;
MSFVKAEPPP VVKNPPPPEY RNPRKPGRLT NQLQYLQKVV IKALWRHSFA WPFQEPVDAV
KLNLPDYYTI IKTPMDLSTI KRRLENNYYW KAMECVEDFN TMFTNCYVYN RPGDDIVLMA
QALEKLFLQK VAQMPQEEVE ITPTVNKEGG KGLTKLKSRS PVSEVVFQQT VTVIPPDALR
AIPSAPLMPA QLSSKIKKGV KRKADTTTPA ASVVTSCESS PTPAEPKPCK LASRRGSGRP
IKPPKKDLPD SQQQHQVGKK PKLSEQLKCC SVILKEMFAK KHAAYAWPFY KPVDTETLGL
HDYHDIIKHP MDLGTIKKKM DDRVYKDAQE FASDFRLMFL NCYKYNPPGH EVVAMARKLQ
DVFEMRFAKI PAGAAERAPP APPVPDERES SSGSDSDSDG SSDSDSSSDA EEERAQRLAQ
LQEQLKAVRD QLQLLSQAPL LKPKKKKKEK SKKEKRKKDR DRRELSRKKG YGDKKKPKSK
AQKMSSKGSL ESKKSKVPGM PCDAEEEEPA LPMTYDEKRQ LSLDINKLPG DKLGKVVNII
QSREPTLRDS NPEEIEIDFE TLKPSTLRAL ERYVMTCLRK RPRKPNLEKK SSKSQEALQS
EKKQELEKRL QHVGERLNPA KKPKSQCEEV APPKGLQGPS QLSDSSSSSS SDSSSSDSST
SDSSDSESEQ KKMKQSNTDI TDVKIIKKEV NQMTTSLWNS AIKRHTEPQT KSNSQPTVTQ
SKQPELNTSQ PLEHEEITVS PPALHTRLPP QPSRPSAKAT PLPLKHRVSS LQADSPPQPP
EPASALQEAV RHPQSSHLPS SGSALSQAAP DPHSHFSPLP LLQSPLTQPE PTPTPLLHPP
QNPPTRAQGE GMSSLLSPLS SPLGPQGPQQ PPSTPSNPAL TCRAVEGMHE IPGSVKLFLN
CLTIILDLLS QWFHKVLPRC SPYLVETCAS KARVVTGVDI VLRNADSWAS LGKMASATPS
MIKSSSESFQ QFRKAAMEKE ERERALRRLQ VEQAGREKKP VPEQPRYCWG AGVWHRLQMG
SPTVRDADRE AAVERVGTPP GPEAPKQEAP LSSVDQERER ARRREQERRR REAMSGIIDM
TLQSDIMATF EKNLY
//
