ID W5MCX8_LEPOC Unreviewed; 194 AA.
AC W5MCX8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Fas associated via death domain {ECO:0000313|Ensembl:ENSLOCP00000006237.1};
GN Name=FADD {ECO:0000313|Ensembl:ENSLOCP00000006237.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006237.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006237.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01035528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006642719.1; XM_006642656.2.
DR AlphaFoldDB; W5MCX8; -.
DR SMR; W5MCX8; -.
DR STRING; 7918.ENSLOCP00000006237; -.
DR Ensembl; ENSLOCT00000006245.1; ENSLOCP00000006237.1; ENSLOCG00000005182.1.
DR GeneID; 102690370; -.
DR KEGG; loc:102690370; -.
DR CTD; 8772; -.
DR eggNOG; ENOG502S2RV; Eukaryota.
DR GeneTree; ENSGT00390000002105; -.
DR HOGENOM; CLU_087961_0_0_1; -.
DR InParanoid; W5MCX8; -.
DR OMA; CKMNLVA; -.
DR OrthoDB; 2960517at2759; -.
DR Proteomes; UP000018468; Linkage group LG27.
DR Bgee; ENSLOCG00000005182; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0031265; C:CD95 death-inducing signaling complex; IBA:GO_Central.
DR GO; GO:0089720; F:caspase binding; IBA:GO_Central.
DR GO; GO:0005123; F:death receptor binding; IBA:GO_Central.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045089; P:positive regulation of innate immune response; IBA:GO_Central.
DR CDD; cd08306; Death_FADD; 1.
DR CDD; cd08336; DED_FADD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR016729; FADD_DD.
DR PANTHER; PTHR15077:SF9; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR15077; FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF01335; DED; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00031; DED; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50168; DED; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 3..81
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 103..187
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 194 AA; 22771 MW; 80E79029EBBD4C49 CRC64;
MSGFLDVLYQ ISQRLSKDNL NSLKFLCVED IKKKKLEQIH QGTELFQCLI EMNKIGPDST
EFLHYLLGHI DRQDLIELLQ KFERDGPAGL NDNQPDVKER EKLDAAFGVI VENMGRDWRM
FARKLGITDA KLDHIREKHP FNMEEQVREV LRVWQKSKGK EAKVMDLIEK LRECKMNLTA
DFVEKELDSM KNFC
//
