ID W5MDA9_LEPOC Unreviewed; 1278 AA.
AC W5MDA9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Ras protein specific guanine nucleotide releasing factor 2 {ECO:0000313|Ensembl:ENSLOCP00000006368.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006368.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006368.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01012348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01012354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015219163.1; XM_015363677.1.
DR AlphaFoldDB; W5MDA9; -.
DR STRING; 7918.ENSLOCP00000006368; -.
DR Ensembl; ENSLOCT00000006376.1; ENSLOCP00000006368.1; ENSLOCG00000005270.1.
DR GeneID; 102699199; -.
DR CTD; 5924; -.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000155679; -.
DR InParanoid; W5MDA9; -.
DR OMA; DHIPKVC; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000005270; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF187; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 239..425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 466..584
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 631..754
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1043..1275
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 735..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..184
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 757..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1278 AA; 145130 MW; 4697A8D85A37A7A9 CRC64;
MQKTVRYNEG HALYLSVVAR KEGTKRGYLS KKTAENSRWH EKYFALYQNV LFYFENEQSA
RPAGIYLLEG CTCERVPAPK MSAAGKETLD KQHYFTITFG HDGQKPLELR TEEETDCEEW
VEAIQQASYS DIIIEREVLM QKYIHLVQIV ETEKVAANQL RHQLEDQDTE IERLKAEIIA
LNKTKERMRP YQGNQEEEDP DIKKIKKVQS FMRGWLCRRK WKTIVQDYIC SPHAESMRKR
NQIVFNMVEA ETEYVHQLYV LVNCFLRPLR MAASSKKPPI SHDDVSSIFL NSETIMFLHE
IFHQGLKARI ANWPTLVLAD LFDILLPMLN IYQEFVRNHQ YSLQVLANCK QNRDFDKLLK
QYEANAACEG RMLETFLTYP MFQIPRYIIT LHELLAHTPH EHVERKSLEF AKSKLEELSR
VMHDEVSDTE NIRKNLAIER MIVEGCDILL DTSQTFVRQG SLIQLPSVER GKLSKVRLGS
LSLKKEGERQ CFLFTKHFLI CTRSSGGKLH LLKQGGVLSL IECTLIEEPD ASDEDSKGTG
QVFGHLDFKI VVEPPDAPSS TVVLLAPSRQ EKAAWTSDIS QCIDNIRCNG LMTSVFEENS
KVTVPHMIKS DARLHKDDVD ICFSKTLNSC KVPQIRYASV ERLLERLTDL RFLSIDFLNT
FLHTYRIFTT AAVVMDKLAD IYKKPFTSIP VRVQYHSSDR LSITSICPDY SLKITRLALD
QSKSLELFFA TNQNSRGGEH AADGKSPRLC RKFSSPPPLS ASRTSSPVRA RKLSLNSPVG
CKAGALDLST SSAASSPTST HTPSVSPPPA ASKAPLDLSR GPSSPEQSPG AGEDGGSEPA
RMDVCGKLRR SIRRAVLESA SLDKFIPESP PAAEPGEISP CRSPSTPRHM RYRQSGVQSA
ENTRCSVSPA SAFAIATAAA GHSSPPGFNN SERMCDKEFI IRRAATNRVL NVLRHWVSKH
SQDFEMNGEL KMGVICLLEE VLRDPDLLPQ ERKATANILS ALSQDDQEDA QLRIEDILQM
KSCPFLYFIM AECPKAECFE TLSAMELAEQ ITLLDHIVFR SIPYEEFLGQ GWMKVDKMER
TPYIMKTSQH FNDMSNLVAS QIMSHTDVGS RANSIEKWVA VGDICRCLHN YNGVLEIISA
LNRSAIYRLK KTWAKVSKQT KALMDKLQKT VSSEGRFKNL RETLKNCNPP CVPYLGMYLT
DLAFIEEGTP NFTEEGLVNF SKMRMISHII REIRQFQQTP YRIEHQPKVT QFLLDKTLTM
DEDTLYDLSL KIEPRLPA
//
