ID W5MDG5_LEPOC Unreviewed; 2083 AA.
AC W5MDG5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Myosin VIIBb {ECO:0000313|Ensembl:ENSLOCP00000006424.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006424.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AHAT01015189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000006424; -.
DR Ensembl; ENSLOCT00000006432.1; ENSLOCP00000006424.1; ENSLOCG00000005313.1.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000157247; -.
DR HOGENOM; CLU_000192_14_1_1; -.
DR InParanoid; W5MDG5; -.
DR OMA; MYEKVWA; -.
DR Proteomes; UP000018468; Linkage group LG14.
DR Bgee; ENSLOCG00000005313; Expressed in intestine and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF24; UNCONVENTIONAL MYOSIN-VIIB ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 61..756
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 927..1229
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1234..1541
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1615..1762
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1768..2071
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 633..655
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 154..161
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2083 AA; 238618 MW; 02E89DADFEC787E5 CRC64;
MVVLRQGDHV WVDSGTGVLI GAEVKLSDTG QLLLIDDEGK EHWVSGKTKE SIRPMHPTSV
KGVDDMIRLG DLNEAGLLRN LMIRHKEGII YTYTGSILVA VNPYQLLPLY TADHVHRYTN
RRLGELPPHV FAIADSCYFN MRRNRKDQCC IISGESGAGK TESTKLMLQF LAAVSGQHSW
IEQQILEANP ILEAFGNAKT IRNDNSSRFG KYIDIYFNKS GVIEGARVDQ YLLEKSRVCR
QAPEERNYHI FYCMLMGMTA EQKNLLSLGN ASEYSYLTVG NCTSCEGRDD IKEYAHIRSA
MKILTFTDNN FWEITKLLAA LLHLGNLDFE AAVYNNMESC DVQASLHFTT AAKLLEVNPK
VLEVSLTNRS FMTNRESVSK PLSCEQAVDG RDAFVKAIYS RLFVWIVNKI NSAVYTAPPA
DPSHVRQSIG LLDIFGFENF NNNSFEQLCI NFANEQLQQF FVKHVFKLEQ DEYAQENIGW
LHIDFNDNQH TLDVLASKSL NILALIEEES HFPKATDTTM LNKINSIHGK SNIYLPPKSK
HDMQFGIQHF AGAVYYNAKG FLEKNRDALS SDSIHLVKTS SNKLLKTIFE ADLISDTVKT
VNPKMIIKPK NSVKATDARK QVPTLSGQFR QSLDSLMKTL TACQPFFIRC IKPNDYKKPM
LFDRDLCMRQ LRYSGMMETI RIRKSGYPIR YAFDEFLERY HVLLKTSVCD PKKETPETCC
SSICESVISA EGDWKIGKTK IFLKDYHDTM LELERDRALH EKATLIQRVL RGYKYRKRFV
KQKKAAVVIQ KTWRGHKCRK QYRVVQLGFA RLQAQCRSRQ LSHRYQQMRE AAVLLQAHCR
GYLLRKDCRR KREAVVVLQA HARGMLARRS VTRMKEEAHL SAQERLTQEM ERRRQREEVL
SRKCEASSKS ESISEQEMVD NIFGFLPTTV HVVSPVISDL LPDLPASLTV WWIILRFMGD
IPEPRQRAPE NKGLGSLGER SIQEKLGQRQ GRRLSHLVGL DQTLILLKII PLDAFLCPLW
RLSTRKSTFK KLLRRNKKAA KSSGGTRNKR QSVVQEEVRK TFLFTDLMKI FQILTTLHSC
ISEKEELSIY ATMTFPAYFQ PVLQPLKEED DVLVGEGPTL DRPMTALEKL HFIVGNGIVR
RNIRDEIYCQ ICKQLVENGN QSSYFRGWIL LSLCLGIFPP SERLSKYLLN FIRSGPAGYA
PYCVERLRRT LTNGVRGEPP TWMELQATKT KKPIVVSVTL MDGRMMSVPL DSASTAQEVC
KFIAQKIKLS DIFGFSVYIA IYEKVWSLGG GKDHVLDAIS QCEQEVKRQG GQEQHAPWRL
YFRKEIFTPW HDCSIDSTST DLIYRQLIRG IRSGEYQCDK EDDMVQLAAK HFYVQFGSDS
GGDNAKKVVQ DCINNSLLEA KSEAKWIQLV GDAYTKSPYI KTKINPDTVK AEVIDFGRHK
WPLFFSRFFE VVKFSGPALP KNTFIVAINW TSISFVDEKE RVLLVLSYPE VVGVNTSRSE
KTHGQTVTLA TLKGDFVLNS PNAANIADLL VMFLEGLKER SQYAVALQEA SKQVLLKAII
AKHVTIYYTC YKIKKCKPKK KRKCIGKKNF ALFVFLSPYN LGTTRFHLYE LTSCSSLELI
NQSFVTENRE KERDLLLKHS SLFLCVLFQA TLIQCEGKLL QDSILIQSTH NKEGLRDEVY
CQIMKQMTDN HNRYSIENGW QLLWLCCGLF PPSQALLKHA QRFLESRRRE PLAADCLQRM
QAALRAEPRK LPPHQVEIDA IQQMSTQIFH KVHFPNDTEE IFEVGSHTRI RDLCHDIAAK
LNLISADGFS LFLKTPDKVL SLNEAEYFFD SLRQITDWTR KVKRVKDGGP VNVPYLVFFM
RKLWFNVTPG KDIQADIIFH YTQELPKYLR GYHRCSKEDM INIAALIFKL KFNNDKSEFV
MIPKMLKELV PNDQLKLMSA EEWRKNIIAS YNKHASLTVN DTKVAILKII HRWPTFGCAF
FEVKQTSEPA FPDIIMIAIS KQGVTLIHPK SKDVLASYPF NKIANWCSGS TYFHMTIGNL
IKGNKILCET SLGYKMDDLL TSYVTMYLNE RNAVHARTNR FPA
//
