ID W5MDL7_LEPOC Unreviewed; 388 AA.
AC W5MDL7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006476.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; AHAT01028894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01028895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MDL7; -.
DR Ensembl; ENSLOCT00000006484.1; ENSLOCP00000006476.1; ENSLOCG00000005361.1.
DR GeneTree; ENSGT00940000160299; -.
DR HOGENOM; CLU_033039_1_3_1; -.
DR Proteomes; UP000018468; Linkage group LG12.
DR Bgee; ENSLOCG00000005361; Expressed in zone of skin and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd19355; Wnt_Wnt10a; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013302; Wnt10.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF89; PROTEIN WNT-10A; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01893; WNT10PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 388 AA; 43842 MW; 7F1DA50801301D7F CRC64;
MGCLALAHSE PAGKRCLIFA RVDSNEILGL KIPFDPILNA NTVCLTLPGL TRRQLDVCMR
NPDVTASAIQ GIQIAIHECQ HQFRGHRWNC SSLETRNKIP YESVVFSRGF RESAFAYAIA
AAGVVHAVSN ACSMGKLKAC GCDEKRRGDE EAFRVKLNRL QLEAINRGKG MVHGVMEHIP
ADAPGPQDSW EWGGCSPDVE FGERFSKDFL DSRETYKDIH ARMRLHNNRV GRQVVMDHMK
RKCKCHGTSG SCQLKTCWQV TPEFRVVGSL LKERFKIATL IKAHNRNTGQ VEHAHPPHRR
RASINELVYF EKSPDFCERQ PESDSAGTQG RICNKTSTEM DNCESLCCGR GHNILQQTRS
ERCNCKFHWC CYVVCEECRI TEWVSVCK
//
