ID W5ME93_LEPOC Unreviewed; 507 AA.
AC W5ME93;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Mucolipin 2 {ECO:0000313|Ensembl:ENSLOCP00000006702.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006702.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006702.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AHAT01018370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5ME93; -.
DR Ensembl; ENSLOCT00000006710.1; ENSLOCP00000006702.1; ENSLOCG00000005533.1.
DR GeneTree; ENSGT00950000183036; -.
DR HOGENOM; CLU_020945_1_1_1; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000005533; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21071; ELD_TRPML2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF4; MUCOLIPIN-2; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 278..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..264
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 313..452
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 507 AA; 58744 MW; 16A2C3A5382FF462 CRC64;
MDFFVRFNET FDSRGSTVTS QDFSAEEEAL REDLRYYFMS PCEKYRMRRK VPWKLGVQIL
KIIMVTTQLV LFGLNNQLVI SYKEENSMTF KNLFLKGYTG TDEDDYSRAV YSQQDVYDCV
FFAIDQYALL KNLSVGPVSY AQDDSEVSPL VICKQHYRRG SVHSSYESND IDPETETVCL
TLDIKTIEDK EWKMANASFF NLDFYRLVNL RISFRLNGIN LQTIRSHELP DCYEFFITIT
FDNQGHSGKM KVYFDSEAIS IACKNCKNIG TVQKNKRYLL VFDVFVIVTC LTSAVLCTRS
IVLAIKLLQS LTSYDVCSIF LGTSTLLVWV GVIRYLGYFQ KYNVLILTMR AAFPKVLRFC
CCAGMIYLGY TFCGWIVLGP YHEKFEGLSR VAECLFSLVN GDDMFATFAQ FQEKSTLVWL
FSRVYLYSFI SLFIYMVLSL FIALITDSYE TIKNYQENGF PMTDLQRFLK RYRDFPSSES
CKEQEAKCSF VCCCNRLEGD EDVLLIS
//
