ID W5MEA1_LEPOC Unreviewed; 883 AA.
AC W5MEA1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Transient receptor potential cation channel subfamily C member 6 {ECO:0000313|Ensembl:ENSLOCP00000006710.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006710.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006710.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AHAT01003092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006628127.2; XM_006628064.2.
DR AlphaFoldDB; W5MEA1; -.
DR STRING; 7918.ENSLOCP00000006710; -.
DR Ensembl; ENSLOCT00000006718.1; ENSLOCP00000006710.1; ENSLOCG00000005553.1.
DR GeneID; 102693540; -.
DR KEGG; loc:102693540; -.
DR CTD; 563989; -.
DR eggNOG; KOG3609; Eukaryota.
DR GeneTree; ENSGT01060000248588; -.
DR InParanoid; W5MEA1; -.
DR OMA; DDGCPQL; -.
DR OrthoDB; 5406916at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000005553; Expressed in pharyngeal gill and 8 other cell types or tissues.
DR GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF7; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 4.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..307
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
SQ SEQUENCE 883 AA; 101300 MW; 42909C734A3D9233 CRC64;
MTQNKSHLSE NHSANINLCL GKRNKSQESL LMNTDFGEES YANYQRNYHA RSNGDRHYNL
LRQTMPKGRR QAVRGPAYMF NARASSLSAE EERFLDAAEY GNIPVVRKML EELPGLNVNC
VDYMGQNALQ LAVANEHLEV TELLLKKDNL ARIGDALLLA ISKGYVRIVE AILSHKAFFN
AKRLTTSPSQ SEIQHDDFFA YDEDGTRFSH DVTPIILASH CYEYEIVHIL LAKGARIERP
HDYFCKCTTC SDNQKHDSFS HSRSRINAYK GLASPAYLSL SSEDPVLCAL ELSNELAVLA
NIEKEFKNDY KKLSMQCKDY VVGLLDLCRN TEEVEAILNG DVDLNPSSEQ HGRPNLIRLK
LAIKYELKKF VAHPNCQQQL LSIWYENLSG LRQQKTAVKF LVVLGVAIGL PFLAMIYWIS
PCSKLGKIMR GPFMKFVAHA ASFTIFLGLL VLNASDRFEG AAPPSNKSNT DNQLYRMQTT
IFTWMEMLII SWVIGMIWAE CKEIWSQGPR EYLLEPWNLL DFGMLAIFVA SFIARFMAYW
HAYRAQCYIN MNNVKNLTNA SLPYEIKYYT FYRKYWLPSD PQLISEGLYA IAVVLSFSRI
AYILPANESF GPLQISLGRT VKDIFKFMVI FILVFLAFMI GMFNLYSHYF TEKQNKAFTT
IEESFKTLFW AIFGLSEVKT VVIGNDHKFI ENIGYVLYGV YNVTMVIVLL NMLIAMINNS
FQEIEDDADV EWKFARAKLW FSYFEEGRTL PVPFNLIPSP KSVVCLVLKI KQFLKVLLRI
QKTDTNGDAE LNELGSDMHS TVRSSNSPTR YQKIMKRLIK RYVFKAQIDK ESDEVNEGEL
KEIKQDISSL RYELLEEKSH NTEDLAELIR KLGEKLSIQT AHQ
//
