ID W5MED4_LEPOC Unreviewed; 920 AA.
AC W5MED4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=PLAT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006743.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006743.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; AHAT01004429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MED4; -.
DR Ensembl; ENSLOCT00000006751.1; ENSLOCP00000006743.1; ENSLOCG00000005583.1.
DR GeneTree; ENSGT00940000154242; -.
DR HOGENOM; CLU_291982_0_0_1; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000005583; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01756; PLAT_repeat; 2.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR Gene3D; 3.10.20.230; Doublecortin domain; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 3.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR45901:SF7; LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45901; PROTEIN CBG12474; 1.
DR Pfam; PF03607; DCX; 1.
DR Pfam; PF00167; FGF; 1.
DR Pfam; PF01477; PLAT; 4.
DR SMART; SM00308; LH2; 4.
DR SUPFAM; SSF50353; Cytokine; 2.
DR SUPFAM; SSF89837; Doublecortin (DC); 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 4.
DR PROSITE; PS50309; DC; 1.
DR PROSITE; PS50095; PLAT; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 1..43
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT DOMAIN 74..190
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 203..320
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 666..780
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 793..910
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 920 AA; 102446 MW; 48362418BA11E007 CRC64;
MQFPVVKLYT PDGRRVDSLQ SLILCSGVVV ASGREPFKPG SYDPQTQTLP AKLPGVSSHV
QPKHRERLGR RNRGKWRVSV VTSSLPSAGT SSQVYIILYG LQGNSGPLFL LGREGDLFQS
GHEDIFDINV GNIGELFKIR IGHNSSGQSP GWHCEEVRLQ NLFTEEMFYL PVNRWLSQEE
EKGGEICREV PVLHHGYPVF PVTLYGVSVV TGDLWNAGTG ANVYINVYGE NGDTGSRQLL
NSKKPTTFCK GQVDTFTLEA VHLGHLEKVV IGHDGLGEGS GWFLEKVVLT DSLKDVEYTF
LCNRWLDQGE MDGKIVTELY VSDGLNYSTR QELEHKRMEI WAVERWKFQK GNIVQLFCKL
TGKCVRLHPD GTVDALGDKR DKQGFFDMRL KRGNIRVFRS LPHPQLTLAI AKGRVTALEN
GGSLCELQVQ IHPNRCVSLE SVQIPGYLVT FDTEGHPADG ATGYSGLCKE FVVHVKGMLR
DGAVIMLNSS VSQALCITRD GRCVGTGRQA EESYFRVHKV CPGVCMFQSL HCPDMYLQVK
GGQCNGRGTG DCYSHFKVEK NYQTGSLSLE SVKCSGMFLG LLPDGSAKPL VHTGVSNVMF
YPQVIQYGRE KPTGTSATPI RWQCKISNQK LYMSYMFKTR AKSKTFADTI TEVKTKRLEP
LVSSDDEWTV SVVTGYPGTQ AQVSLWIYGS EGNAGPILLE KSNRDTLFSP KQEDEFQLAM
TNIGEIYKIR IGHDGTSDHP DWNLQSVSLR KNKDGPTLQF SVNRWLSRNH GNGDILCEVA
AMKEDGQPIF PVVKYQVTIY TGHLNHAETQ SPVLICLYGE RGDSGLRLLH KAQLANTFRR
GQVDAFELEA VSLGKLQKVL LCCEAKNKSD YWYCEKVIIG EPGGGSEYIF NCESERWIPF
SSEGVVKTGI ELQVQGYNDF
//
