ID W5MF94_LEPOC Unreviewed; 317 AA.
AC W5MF94;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Si:dkey-23c22.5 {ECO:0000313|Ensembl:ENSLOCP00000007053.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007053.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007053.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; AHAT01009808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01009809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01009810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MF94; -.
DR STRING; 7918.ENSLOCP00000007053; -.
DR Ensembl; ENSLOCT00000007061.1; ENSLOCP00000007053.1; ENSLOCG00000005841.1.
DR eggNOG; ENOG502S1XZ; Eukaryota.
DR GeneTree; ENSGT00950000183126; -.
DR HOGENOM; CLU_076255_0_0_1; -.
DR InParanoid; W5MF94; -.
DR OMA; PGMYCKS; -.
DR Proteomes; UP000018468; Linkage group LG25.
DR Bgee; ENSLOCG00000005841; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IBA:GO_Central.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; IBA:GO_Central.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IBA:GO_Central.
DR GO; GO:2000406; P:positive regulation of T cell migration; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13405; TNFRSF14_teleost; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 5.
DR InterPro; IPR008063; Fas_rcpt.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR46838; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR PANTHER; PTHR46838:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR Pfam; PF00020; TNFR_c6; 4.
DR PRINTS; PR01680; TNFACTORR6.
DR SMART; SM00208; TNFR; 6.
DR SUPFAM; SSF57586; TNF receptor-like; 5.
DR PROSITE; PS00652; TNFR_NGFR_1; 3.
DR PROSITE; PS50050; TNFR_NGFR_2; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..38
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 4..38
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 40..82
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 40..82
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 106..146
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 106..146
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 148..190
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 148..190
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DISULFID 17..30
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 20..38
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 41..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 125..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 128..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 149..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 317 AA; 34593 MW; B572208A453E8E2A CRC64;
MCEACDSQEY AHGEICCPKC NRGERVAKNC TDTTSTLCKT CPESTYMDHP NELNECKRCQ
KCEAEEGMIT KLRCSPTSNS VCECGEGFFC SVPADRGCSK CLNHTVCSEG QFTKQNEYLV
NGECCPMCPI GSRVLRHCTE FSNTSCIPCV GPTYTDQPNG LLSCFPCKVC DPGLGLRTLH
GCTNQKDTVC WVLSGYYCID QADGGCRAAR PHTVCAPGQW VKQPGSDSTD TECEDCPQNS
YSDGLFTSCK PHTDCEARGL QEIRPGTSAS DVECGEMSNP VVPIVTVLAI FIPISIRVVI
FLVLKKKIPF LKGKVKQ
//
