ID W5MFC4_LEPOC Unreviewed; 1061 AA.
AC W5MFC4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Si:ch73-215d9.1 {ECO:0000313|Ensembl:ENSLOCP00000007083.1};
GN Name=KIAA0319 {ECO:0000313|Ensembl:ENSLOCP00000007083.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007083.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007083.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AHAT01017928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MFC4; -.
DR Ensembl; ENSLOCT00000007091.1; ENSLOCP00000007083.1; ENSLOCG00000005830.1.
DR GeneTree; ENSGT00940000161462; -.
DR Proteomes; UP000018468; Linkage group LG11.
DR Bgee; ENSLOCG00000005830; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029865; KIAA0319-like.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR46182:SF1; DYSLEXIA-ASSOCIATED PROTEIN KIAA0319; 1.
DR PANTHER; PTHR46182; FI19480P1; 1.
DR Pfam; PF18911; PKD_4; 1.
DR SMART; SM00765; MANEC; 1.
DR SMART; SM00089; PKD; 5.
DR SUPFAM; SSF49299; PKD domain; 4.
DR PROSITE; PS50986; MANSC; 1.
DR PROSITE; PS50093; PKD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 945..970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..87
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 537..609
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 199..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 116327 MW; EFEF4710853BBFC8 CRC64;
LFLCTTGAFA DPCWQGVTFS ETIISPNLKN TNILRVPDVV SLTQCAGACC DFPGCDLAWL
FERHCYIVNC KHKENCEPKK RPGTDSYMIF LQRRPPQTLV LQSLVRGQPF SGRVRPQSNL
KGPESLKDLA LFDGDQAFED SSLAEDEYPE SYRSSIIHGS PVGSRAEQKE SSGYLDWLSV
AGKEGFNFSE YGVSQGDLYT SQSPSKSSLL QRSTSTKGEI DRGDAPTVPA PATPVSLSGQ
LLVASLLKLQ SLYGTPAILD DVPLHNISLT SMEMMPTSHN STADFISEIQ IQPSLPDVPS
SPPTSTSSPT TTLTPGTAEG TSVKALVVSA GDNVEVTLPR NTVELNAFVF PEPKTEVSYS
YEWSLISHPA DYEGEMENKH TKTLKLSRLS PGLYIFKVCV TAGSSYGEGF VNITVKAATQ
VNQPPVAIAS PWIQEISLPT TSTYIDGSQS TDDDKIVSYH WEEVTGPLRE QKASADTAIL
HLYDLVPGNY TFRLTVIDSD GAANSTTATV LVHKPTDYPP VANAGPNQAI TLPHNYITLS
GNQSSDDHGI VSYEWSLSPA SKGKVVAIQG VRTPYLQLSA MQEGDYTFQL TVTDSAGQQA
TAMVTVIVQP ENNSPPQAVV GPDKELTFPA ESTTLDGSRS TDDQGVVSFL WDCISGPSGA
KIEKADKPLA IVTGLRIGTY KFRLTVKDQQ GLTSDGIITV TLKEEKNAPP VARAGGSHVL
VLPNNSVILD GSASTDDQGI VSYRWVRDGQ SPASGDVIYG SEHQAVLHLT NLVEGTYIFQ
LHVTDAKGYS STDAATVEVC PDPHRKDEVE LELYVGVSQL NQQQKDTVVR QLAVLLNVLD
SDIIVQKVQA QTELSTVMSF YVRGREGILQ GPQLTRTLRG QLLKEKSDFL LFRVLRVDTA
VCLLRCSEHG QCDPITKHCV CDPFWVENPV HRYFNDGESN CEWSVLYVII TSFVMVILIM
GLSWACVCCC KRTRRTKVRK KTKYTILDNI DEQERMVLRP KYNIKHRSTE HNSSLMISES
EFESEQDTIF TREKVDKEKM KNSSNGSAQN GDVFSFHPED R
//
