ID W5MFD0_LEPOC Unreviewed; 471 AA.
AC W5MFD0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007089.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007089.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR EMBL; AHAT01005837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MFD0; -.
DR STRING; 7918.ENSLOCP00000007089; -.
DR Ensembl; ENSLOCT00000007097.1; ENSLOCP00000007089.1; ENSLOCG00000005871.1.
DR eggNOG; KOG0297; Eukaryota.
DR GeneTree; ENSGT00940000158628; -.
DR HOGENOM; CLU_021061_6_0_1; -.
DR InParanoid; W5MFD0; -.
DR OMA; EWPFAYK; -.
DR Proteomes; UP000018468; Linkage group LG22.
DR Bgee; ENSLOCG00000005871; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Ensembl.
DR GO; GO:0002072; P:optic cup morphogenesis involved in camera-type eye development; IEA:Ensembl.
DR GO; GO:0003405; P:optic vesicle elongation; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd03781; MATH_TRAF4; 1.
DR CDD; cd16641; mRING-HC-C3HC3D_TRAF4; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR037307; TRAF4_MATH.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF144; TNF RECEPTOR-ASSOCIATED FACTOR 4; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 4.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 18..59
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 102..155
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 157..209
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 211..267
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 308..463
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 102..155
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 157..209
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 211..267
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
SQ SEQUENCE 471 AA; 54384 MW; 0A369E548FA0EBFB CRC64;
MPGFDYKFLE KPKRRFQCPL CNKAMREPVQ VSTCGHRFCD TCLQEFLSSE GVFKCPEDQL
PLDYAKIYPD PDLEQQILSL SIRCIHSEEG CRWTGQMKQL QSHFSTCAFN VIPCPNRCAI
KLTRRDLPDH LQHDCPKRKV KCEFCGNEFT GEAYENHQGI CPQESVYCEN KCGARMMRRL
LSQHSLAECP KRTQPCKYCG KEFVYDTIQN HQYHCPRFPV QCPNQCNALN VPREDLASHL
KESCGSALVL CPFKDAGCKH RCPKVAMGRH LEDTSKAHLT LMCSLVSRQR QEIQELRREM
EELSVSHDGV LIWKISDYSR KLQEAKLRNN YEFFSPPFYT HKYGYKLQVS AFLNGNGSGE
GTHLSIYIRV LPGEYDSLLE WPFSYKVTFS ILDQSDPSLS KPQHITETFN PDPNWKNFQK
PGSSRNSLDE STLGFGYPKF ISHEEIKKRN YIRDNAIFLK ASIEIPQKII A
//
