ID   W5MGL2_LEPOC            Unreviewed;       523 AA.
AC   W5MGL2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Aminopeptidase like 1 {ECO:0000313|Ensembl:ENSLOCP00000007521.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007521.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000007521.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M17 family.
CC       {ECO:0000256|ARBA:ARBA00009528}.
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DR   EMBL; AHAT01024342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01024343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006639705.1; XM_006639642.2.
DR   AlphaFoldDB; W5MGL2; -.
DR   STRING; 7918.ENSLOCP00000007521; -.
DR   MEROPS; M17.006; -.
DR   Ensembl; ENSLOCT00000007529.1; ENSLOCP00000007521.1; ENSLOCG00000006225.1.
DR   GeneID; 102691441; -.
DR   KEGG; loc:102691441; -.
DR   CTD; 79716; -.
DR   eggNOG; KOG2597; Eukaryota.
DR   GeneTree; ENSGT00530000063255; -.
DR   HOGENOM; CLU_013734_3_1_1; -.
DR   InParanoid; W5MGL2; -.
DR   OMA; MVCEQSD; -.
DR   OrthoDB; 2899215at2759; -.
DR   Proteomes; UP000018468; Linkage group LG18.
DR   Bgee; ENSLOCG00000006225; Expressed in intestine and 13 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd00433; Peptidase_M17; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   Gene3D; 3.40.50.10590; Zn-dependent exopeptidases; 1.
DR   InterPro; IPR011356; Leucine_aapep/pepB.
DR   InterPro; IPR041417; NPEPL1_N.
DR   InterPro; IPR000819; Peptidase_M17_C.
DR   PANTHER; PTHR11963:SF4; AMINOPEPTIDASE NPEPL1-RELATED; 1.
DR   PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR   Pfam; PF18295; Pdase_M17_N2; 1.
DR   Pfam; PF00883; Peptidase_M17; 1.
DR   PRINTS; PR00481; LAMNOPPTDASE.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00631; CYTOSOL_AP; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT   DOMAIN          340..347
FT                   /note="Cytosol aminopeptidase"
FT                   /evidence="ECO:0000259|PROSITE:PS00631"
FT   REGION          501..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..523
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  55626 MW;  39F2099D20ED8ACD CRC64;
     MANVVLEFKA AAGDSEPQSR PVLVVGRLAN LQQVTWAEVK GKLQPTVSKE TWQSALSALN
     PNPTDSCPLY LSYASVAALP SRVSRHNSPS AAHFLTRLVR SCLPGGASRC IVVVCERSEV
     FASACAVARA FPLFSRRSSA SRRADKRLVV VEFVTVGEDN GPLDLGTLEC LSSTADGVRL
     AARIVDTPCN EMNTDHFLEE IKAVGNELRI VPVIIRGEEL REKGFGGIYG VGKAAEYPPA
     LAVLSHTPEG ATQTIAWVGK GIVYDTGGLS IKGKTTMPGM KRDCGGAAAV LGAFRAAVKQ
     GFKDNLHAVF CLAENSVGPN ATRPDDIHTL YSGKTVEINN TDAEGRLVLS DGVAYASRDL
     AADIILDMAT LTGAQGISTG KYHAAVMTNS EEWEAACVRA GRSSGDLAHP LVYCPELHFS
     EFTSAVADMK NSVADRENAQ SSCAGLFIGS HLGFDWPGVW VHVDIASPVH AGERATGFGV
     ALLLALFGQA SEDPLLNLVS PLGGQDRGRP EQMERDCKRR RLV
//