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Database: UniProt
Entry: W5MGY9_LEPOC
LinkDB: W5MGY9_LEPOC
Original site: W5MGY9_LEPOC 
ID   W5MGY9_LEPOC            Unreviewed;      1653 AA.
AC   W5MGY9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007648.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000007648.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the MADD family.
CC       {ECO:0000256|ARBA:ARBA00005978}.
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DR   EMBL; AHAT01030832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01030840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7918.ENSLOCP00000007648; -.
DR   Ensembl; ENSLOCT00000007657.1; ENSLOCP00000007648.1; ENSLOCG00000006317.1.
DR   eggNOG; KOG3570; Eukaryota.
DR   GeneTree; ENSGT00940000156718; -.
DR   HOGENOM; CLU_001270_1_0_1; -.
DR   InParanoid; W5MGY9; -.
DR   OMA; SHIGFIY; -.
DR   Proteomes; UP000018468; Linkage group LG27.
DR   Bgee; ENSLOCG00000006317; Expressed in camera-type eye and 12 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0032483; P:regulation of Rab protein signal transduction; IBA:GO_Central.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR039980; MADD.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT   DOMAIN          13..568
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          103..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          613..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          909..936
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1049..1109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1145..1266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..634
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        701..726
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        914..936
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1145..1159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1160..1215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1234..1253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1653 AA;  182966 MW;  F015D01629DC7B0F CRC64;
     MEKRKPCPRL LDYLVVVGAR QPSSDSVAQT PELLRRYPLE DHADFPLPPD VVFFCQPEGC
     LSARQRRMSL RDDTSFVFTL TDKDTGVVRY GICVNFYRSF QKRPGKPDRP EGHRGRGEKA
     KAPPASAAPA APDEAGSESS ESGSSLQPPS AESTPDVNRS PRGKRCAKPA QRSRNSTLTS
     LCVLSHYPFF STFRECLYIL KRLVDCCSER LTKKAGIPKG VQRDTMWRVF TGALSVEEKS
     SALLQDLREI ESWVYRLLRS PVPAAGQKRV DVEVLPHEMQ PALTFALPDP SRLSLVDFPL
     HLPLELLGVD ACLQVLTCIL LEHKVVLQSR DYNALSMSVM AFVAMIYPLE YMFPVIPLLP
     TCMASAEQLL LAPTPYIIGV PASFFLYKSD FKMPDDVWLV DLDCNKVIIP KNADFLPVLP
     EPESAELKKH LKQALASMSL NTQPILNLEK FHEGQEMPLL AGRGREDHTS TPSTEFNPLI
     YGNDVDSVDV ATRVAMVRFF NSPNVLQGFQ MHTRTLRLFP RPVVAFQANS FLASRPKQSG
     FAEKLAHTQA VEYFGEWSLN PTNLAFQRIH NNVYDPSLIG DKPKWYAHQL QPIYYRVYDG
     NSLLAEAMTA PLEREDDDDD DDSDPTDDSG SDSVDYDDSS SSYSSLGDFV SEMMKCDIKG
     DTPSNVDPLT HAALGDASEV EFQDFQEYRV EVDDPALDSE TSLENHQPRS SSSTTASSSP
     STIIQGVNHE PCEAADAEEK AATGAPTAPP VGGAQPFAKP GPERRESEAA AAAPADGALK
     KRDYDNPYFE PQYGFPTEED GEGDEQEESY TPQFNQNING NNPVNPPEMS VLQLFSGEVI
     GVNDSKSCRD RRSVVQHRTK GRSKVQLYLC NLYKNHSTSF SLSNLALPKA ARDKTTPFPS
     LKGNRRALVD QKSSVIKHSP TVKKESPSPQ GRANNTSENQ QFLKEVVQSV LEGQGVGWLN
     MKKVRRLLEN EQLRVFVLSK LSRAVQSEED ARQDVIHDVE VSRKVYKGML DLLKCTVSSL
     EHSYTNAGLG GMASVFSLLE IARTHYYTKD PEKRKRSPTE GGSSPGSKES LTPRGESARP
     AGPLLVPKIQ LPPGAAPSAG KGPRQFDTRS LNEENFIASI ELWSKYQDNR KQKAMEKLRA
     EGVKQFSDVG DREEKKSQIS ADSGLSVTSG SQKSDTESIA SSEPSGLTRS TSQESEASTV
     VSNSSGETLG ADSDLSSSAG DGPAGKLAAH LATSRGTLSD SEIETNPATS SVFGKTHMLK
     PGRGSLPGRM APPVALEDVS MRVYLCEGLL GRDKSSMWDQ LEDAAMETFS LSNDGLFTLP
     CFVSPGGKKK ILAACLPSCG WGGDPGPGEL VPPRYLSLGG HDRKRLEDDE DRLLATLLHN
     MIAYMLMVKM NKNDIRKKVR RLMGKSHIGL VYSQEINDVL DRLPELTGRE LPIRPSGSRH
     IKKQTFVVHA GTDTTGDIFF MEVCDDCIVL RSNIGTVYER WWYEKLINMT YCPKTKVLCL
     WRRNGQETQL NKFYTKKCRE LYYCVKDSME RAAARQQSIK PGPELGGEFP VQDMKTGEGG
     LLQVTLEGIN LKFMHSQVFI ELSHIKKCNT VKGVFVLEEF VPETKEVVIH KYKTPMAHQI
     CYSVLCLFSY MAAVRGKEVE SKPKALCPRP VPS
//
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