ID W5MGY9_LEPOC Unreviewed; 1653 AA.
AC W5MGY9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007648.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MADD family.
CC {ECO:0000256|ARBA:ARBA00005978}.
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DR EMBL; AHAT01030832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000007648; -.
DR Ensembl; ENSLOCT00000007657.1; ENSLOCP00000007648.1; ENSLOCG00000006317.1.
DR eggNOG; KOG3570; Eukaryota.
DR GeneTree; ENSGT00940000156718; -.
DR HOGENOM; CLU_001270_1_0_1; -.
DR InParanoid; W5MGY9; -.
DR OMA; SHIGFIY; -.
DR Proteomes; UP000018468; Linkage group LG27.
DR Bgee; ENSLOCG00000006317; Expressed in camera-type eye and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0032483; P:regulation of Rab protein signal transduction; IBA:GO_Central.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR039980; MADD.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 13..568
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 103..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..634
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1653 AA; 182966 MW; F015D01629DC7B0F CRC64;
MEKRKPCPRL LDYLVVVGAR QPSSDSVAQT PELLRRYPLE DHADFPLPPD VVFFCQPEGC
LSARQRRMSL RDDTSFVFTL TDKDTGVVRY GICVNFYRSF QKRPGKPDRP EGHRGRGEKA
KAPPASAAPA APDEAGSESS ESGSSLQPPS AESTPDVNRS PRGKRCAKPA QRSRNSTLTS
LCVLSHYPFF STFRECLYIL KRLVDCCSER LTKKAGIPKG VQRDTMWRVF TGALSVEEKS
SALLQDLREI ESWVYRLLRS PVPAAGQKRV DVEVLPHEMQ PALTFALPDP SRLSLVDFPL
HLPLELLGVD ACLQVLTCIL LEHKVVLQSR DYNALSMSVM AFVAMIYPLE YMFPVIPLLP
TCMASAEQLL LAPTPYIIGV PASFFLYKSD FKMPDDVWLV DLDCNKVIIP KNADFLPVLP
EPESAELKKH LKQALASMSL NTQPILNLEK FHEGQEMPLL AGRGREDHTS TPSTEFNPLI
YGNDVDSVDV ATRVAMVRFF NSPNVLQGFQ MHTRTLRLFP RPVVAFQANS FLASRPKQSG
FAEKLAHTQA VEYFGEWSLN PTNLAFQRIH NNVYDPSLIG DKPKWYAHQL QPIYYRVYDG
NSLLAEAMTA PLEREDDDDD DDSDPTDDSG SDSVDYDDSS SSYSSLGDFV SEMMKCDIKG
DTPSNVDPLT HAALGDASEV EFQDFQEYRV EVDDPALDSE TSLENHQPRS SSSTTASSSP
STIIQGVNHE PCEAADAEEK AATGAPTAPP VGGAQPFAKP GPERRESEAA AAAPADGALK
KRDYDNPYFE PQYGFPTEED GEGDEQEESY TPQFNQNING NNPVNPPEMS VLQLFSGEVI
GVNDSKSCRD RRSVVQHRTK GRSKVQLYLC NLYKNHSTSF SLSNLALPKA ARDKTTPFPS
LKGNRRALVD QKSSVIKHSP TVKKESPSPQ GRANNTSENQ QFLKEVVQSV LEGQGVGWLN
MKKVRRLLEN EQLRVFVLSK LSRAVQSEED ARQDVIHDVE VSRKVYKGML DLLKCTVSSL
EHSYTNAGLG GMASVFSLLE IARTHYYTKD PEKRKRSPTE GGSSPGSKES LTPRGESARP
AGPLLVPKIQ LPPGAAPSAG KGPRQFDTRS LNEENFIASI ELWSKYQDNR KQKAMEKLRA
EGVKQFSDVG DREEKKSQIS ADSGLSVTSG SQKSDTESIA SSEPSGLTRS TSQESEASTV
VSNSSGETLG ADSDLSSSAG DGPAGKLAAH LATSRGTLSD SEIETNPATS SVFGKTHMLK
PGRGSLPGRM APPVALEDVS MRVYLCEGLL GRDKSSMWDQ LEDAAMETFS LSNDGLFTLP
CFVSPGGKKK ILAACLPSCG WGGDPGPGEL VPPRYLSLGG HDRKRLEDDE DRLLATLLHN
MIAYMLMVKM NKNDIRKKVR RLMGKSHIGL VYSQEINDVL DRLPELTGRE LPIRPSGSRH
IKKQTFVVHA GTDTTGDIFF MEVCDDCIVL RSNIGTVYER WWYEKLINMT YCPKTKVLCL
WRRNGQETQL NKFYTKKCRE LYYCVKDSME RAAARQQSIK PGPELGGEFP VQDMKTGEGG
LLQVTLEGIN LKFMHSQVFI ELSHIKKCNT VKGVFVLEEF VPETKEVVIH KYKTPMAHQI
CYSVLCLFSY MAAVRGKEVE SKPKALCPRP VPS
//