ID W5MHE7_LEPOC Unreviewed; 898 AA.
AC W5MHE7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Exosome component 10 {ECO:0000313|Ensembl:ENSLOCP00000007806.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007806.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007806.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; AHAT01009817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01009818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MHE7; -.
DR STRING; 7918.ENSLOCP00000007806; -.
DR Ensembl; ENSLOCT00000007816.1; ENSLOCP00000007806.1; ENSLOCG00000006443.1.
DR eggNOG; KOG2206; Eukaryota.
DR GeneTree; ENSGT00390000015408; -.
DR HOGENOM; CLU_010129_1_1_1; -.
DR InParanoid; W5MHE7; -.
DR OMA; NIMRPQM; -.
DR Proteomes; UP000018468; Linkage group LG25.
DR Bgee; ENSLOCG00000006443; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0071044; P:histone mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071040; P:nuclear polyadenylation-dependent antisense transcript catabolic process; IBA:GO_Central.
DR GO; GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IBA:GO_Central.
DR GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071036; P:nuclear polyadenylation-dependent snoRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071037; P:nuclear polyadenylation-dependent snRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 507..589
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 102852 MW; 9B1A6BC508769E0D CRC64;
KMAASTSRSG RGKGNNISPT NEEAEGEKPE LLPGFKDADS FVKHGLGTVV AATKASANLP
QAGDEFDFYR SFPGFQEFCE TQGERLLQCM SQLMQYHSCK SHMRDRNKVT GLEERFDLLV
DSNDVILERV GILLDEASGV NRNQQPILPA GIQPPKTIVS SWNRKSRDSS KAAKSETFRL
LHAKNIQRPQ LKFREKVDNS NTPFVPKIFV KPNALKSLPT YFTDQKIRKE RPEDLDVPPA
LADFIHQQRT QQHLDDMFAH PYQYELDHFT VPENLLSKPE PQMYKPLAET NCQFINSMED
LVELNEKLAK CSEFAVDLEH HSYRSFLGLT CLMQISTRDE DFIIDTLELR SEMYILNETF
TDPSIVKVFH GADSDIEWLQ KDFGLYVVNM FDTHQAARVL NLGRHSLDHL LKLYCGVDSD
KQYQLADWRI RPLPEEMFQY ARADTHYLLY VYDRLCKELY ECGNEQPALL QMVWQKSRDV
ALKKYTKPIF TEESYLELYR KQKRMFNVQQ LAALRLLFAW RDKLARQEDE STGYRYVLPN
HMLIKISEEL PREPQGIIAC CNPVPPLVRQ QVNELHLLVQ QARETPLLKT EPVTSEKKKG
FTLKRKSKNV LFGPHDDSHV SEDDFPDFTS HGAPVKQGAL FSEETGASDD WSSLLASAKI
TIFEHSGTDT EKSGYLTVAQ QKAHSILASF ENPFRMYLPS KDNNIHLSEN AKYDPSSKVY
EISNRWKLLS QEQQKKDAEA KEEARKKARE AAQKAAEERK KAQKNYKESL QNVVTVRQQA
VMAAAEQEGK KRQPNPSESG AEIPKPERKR PKATEQPAQQ GAPVPADFKP FDYSKSDFKV
FAGGKSKEST QFDPNKQAQE PKRKKNPKGH RMNSAGNKSM SYLAGKSERG FRHNWPKR
//
