ID W5MHL6_LEPOC Unreviewed; 1028 AA.
AC W5MHL6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Integrin alpha 4 {ECO:0000313|Ensembl:ENSLOCP00000007875.1};
GN Name=ITGA4 {ECO:0000313|Ensembl:ENSLOCP00000007875.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007875.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007875.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AHAT01020117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MHL6; -.
DR STRING; 7918.ENSLOCP00000007875; -.
DR Ensembl; ENSLOCT00000007885.1; ENSLOCP00000007875.1; ENSLOCG00000006512.1.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000158443; -.
DR HOGENOM; CLU_004111_5_0_1; -.
DR InParanoid; W5MHL6; -.
DR OMA; YLHDNAM; -.
DR Proteomes; UP000018468; Linkage group LG12.
DR Bgee; ENSLOCG00000006512; Expressed in mesonephros and 13 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0043114; P:regulation of vascular permeability; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF78; INTEGRIN ALPHA-4; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 973..997
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 35..100
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 290..349
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 352..409
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 413..475
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 460..617
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 625..765
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 774..952
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1028 AA; 114733 MW; EE2C0CF02B01AA16 CRC64;
INDPVYCYSM LLKKNVIILI YLYTVLLYSK AECYNLDIEN HVIFNGPKGS LFGYSVLLHS
HENQNWLLVG APIANSSSNQ AIVNPGAIFK CNINDINHCE QLPVGIEEDN SCGRHCLAEK
DNQWLGVSLS RQSEEGYIVA CGHRWKNVFY MHKENQHKLP HGICYKISPD LTFQQTLTPC
YKDHQRKFGE SYGSCQAGIS NYLTKDLIIM GAPGTFYWTG SVLVYNMSSR SLWAYVDNEN
HVLFGSYLGY SVGAGHFSHP DSTEFVGGAP QHGQTGKAYI LSFGSTSTLE IIFELSGKML
GSYFGASVCA VDLNSDGLSD LLVGAPMHST VREEGRVYVY MNLGKAKLQE LEFELVGSDM
YSARFGETIT NLGDIDDDGF PDVAIGAPQE EDLQGAIYIY NGRKRGISQT FSQKITGSII
GNAFKMFGQS VSGRIDVDGN GYPDVAVGAF LSDSAIVLRT RAVVIVEVSM ILPPSVNRTK
PACTENGKPA VCMNVTLCFQ IKGRYIPGYI GLLYNLTADV LRKEGFPYRF YFIGNGTSNG
TSGKINALHN RMSCVTHQAY MRKEVRDIFT PIQFEATYQL GEHKVNKRDS SHLQDLKPIL
QQREGDNNIV SNKTMFARYC VWPNCSTNLR VSAGLVLPQS HKGKSYFALG NGKTIMLNVS
LFNAGDDAFQ AALHIRFPNM LYFIKVLDSE EKHISCEITE QEQPTVGLDC SVGNLYINSL
TRVNVSFLLD VNRNSSAGDL TITVNATSDN AEDTNLQHDN FVSLVLPLRY GVDLNVHGFV
SPSLFVFGEE KEGPCYSEKF NYTFSVINVG LSKSPDTKFK ISLPNSLAPH PYQLFNALDI
RSSLGQCHLL NVINKTDDDK CDLPKATFLE DVVFFFSKTG KRFMYCMEED DLCLNIICEF
GEMDIGKEAI VYLEVELNPS VLELSPGRAP VMRIQTTATA FPKNDPYIIK LQDNPFTTIV
LEAHHDYKPR HGVGLFIISG SLLIGLVILG LLTYILWKVG FFKRKFTTEK EQQRRESWDY
VDKIKDDY
//
