ID W5MHM6_LEPOC Unreviewed; 727 AA.
AC W5MHM6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Complement factor B-like {ECO:0000313|Ensembl:ENSLOCP00000007885.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007885.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AHAT01018383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015193088.1; XM_015337602.1.
DR AlphaFoldDB; W5MHM6; -.
DR Ensembl; ENSLOCT00000007895.1; ENSLOCP00000007885.1; ENSLOCG00000006515.1.
DR GeneID; 102694189; -.
DR KEGG; loc:102694189; -.
DR GeneTree; ENSGT00940000158605; -.
DR OrthoDB; 3594820at2759; -.
DR Proteomes; UP000018468; Linkage group LG26.
DR Bgee; ENSLOCG00000006515; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006956; P:complement activation; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00033; CCP; 3.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011360; Compl_C2_B.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46393:SF8; COMPLEMENT C2; 1.
DR PANTHER; PTHR46393; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00084; Sushi; 3.
DR Pfam; PF00089; Trypsin; 1.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF001154; Compl_C2_B; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00032; CCP; 3.
DR SMART; SM00020; Tryp_SPc; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50923; SUSHI; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..727
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866147"
FT DOMAIN 35..94
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 103..162
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 165..222
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 271..470
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 499..727
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT ACT_SITE 530
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT ACT_SITE 581
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT ACT_SITE 709
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT DISULFID 133..160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 193..220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 727 AA; 80577 MW; 96C7EA462581EE74 CRC64;
MRTQVCAVAV VLALTFAVGK TEEAPEGEDD DVEAKGCPQA EAIEGGRVSY SQGGSVGSEL
TYHCDEGWYP YPVRQRVCDA EGAWSTMRLP SGRSTTRAIC KEVQCPAQLQ LDNGVFSPRK
LWFRPGESQQ FWCQEGFKLY GSEVRNCTSG GDWTGSTPVC DDRVEDCVNP GAPPGSLRSG
SRFRVGETVQ YRCHQGLELL GSSDRVCLSA RVWSGSEPRC LALFSFDSPA VVATALGASL
SAVMDLSYIQ DKKGTGSFGR TIRIEDDGKL NVYILLDTSG SINPKYFDEA KDAVLTLIRK
LDSYEVEQKY EVISYASQAK EIVSILDPES NNVEYVIDKL YEFKYTAHGD KTGTNLHAAL
NMVYRNMGFL KENKGSKFNQ TRHVILIVSD GHSNTGGSPK SVLNKIRSLL GIHMPSLDNT
NEDYLDIYVF GVGDKVNKRE LNSIASQKRD EEHLFILKGP EELGKVFDQM ISDSAVTMCG
VAQESEAQLE ELKVGYVNPW HVEVKTVSIE KKENCRGTIL TQSWILTAAH CFTQDMVEEP
KKVSILFNAS TSDVATAIVL HPQYDIQGLL HKKVKEFYDY DVALVKVKNK IGFSERSRPV
CLPCTVPSAR ALKIKANSTC DEHLKALFRT EEIPANFLTK AEQLTEKKQV ERKQTHIQYG
SRRPACIEKA KVALEPDSTA DVSEFVTDRF LCTGGSSSYK DSIACKGDSG GALFVQQKRR
YFQVCEN
//
