ID W5MIC7_LEPOC Unreviewed; 200 AA.
AC W5MIC7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Solute carrier family 25 member 1a {ECO:0000313|Ensembl:ENSLOCP00000008136.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008136.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008136.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in);
CC Xref=Rhea:RHEA:72483, ChEBI:CHEBI:15589, ChEBI:CHEBI:16947;
CC Evidence={ECO:0000256|ARBA:ARBA00036668};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cis-aconitate(in) + citrate(out) = cis-aconitate(out) +
CC citrate(in); Xref=Rhea:RHEA:72475, ChEBI:CHEBI:16383,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00036042};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-
CC isocitrate(out); Xref=Rhea:RHEA:72471, ChEBI:CHEBI:15562,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00036585};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + maleate(in) = citrate(in) + maleate(out);
CC Xref=Rhea:RHEA:72491, ChEBI:CHEBI:16947, ChEBI:CHEBI:30780;
CC Evidence={ECO:0000256|ARBA:ARBA00036819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + phosphoenolpyruvate(in) = citrate(in) +
CC phosphoenolpyruvate(out); Xref=Rhea:RHEA:72487, ChEBI:CHEBI:16947,
CC ChEBI:CHEBI:58702; Evidence={ECO:0000256|ARBA:ARBA00036159};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + succinate(in) = citrate(in) + succinate(out);
CC Xref=Rhea:RHEA:28835, ChEBI:CHEBI:16947, ChEBI:CHEBI:30031;
CC Evidence={ECO:0000256|ARBA:ARBA00036264};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + trans-aconitate(in) = citrate(in) + trans-
CC aconitate(out); Xref=Rhea:RHEA:72479, ChEBI:CHEBI:15708,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00035792};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; AHAT01006032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MIC7; -.
DR STRING; 7918.ENSLOCP00000008136; -.
DR Ensembl; ENSLOCT00000008146.1; ENSLOCP00000008136.1; ENSLOCG00000006737.1.
DR eggNOG; KOG0756; Eukaryota.
DR GeneTree; ENSGT00940000165695; -.
DR HOGENOM; CLU_015166_5_3_1; -.
DR InParanoid; W5MIC7; -.
DR OMA; YSEEHTI; -.
DR Proteomes; UP000018468; Linkage group LG22.
DR Bgee; ENSLOCG00000006737; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0010821; P:regulation of mitochondrion organization; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR049563; TXTP-like.
DR PANTHER; PTHR45788; SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR45788:SF7; TRICARBOXYLATE TRANSPORT PROTEIN A, MITOCHONDRIAL; 1.
DR Pfam; PF00153; Mito_carr; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transport {ECO:0000256|RuleBase:RU000488}.
FT REPEAT 11..97
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 107..192
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 200 AA; 22185 MW; 2C3DF7B4C9249FE6 CRC64;
MRDAAGRLDS SRSLLCGLAA GVAEAVLVVC PMETIKVKFI HDQCSSRPRY RGFFHGIREI
IRDQGLRGTY QGLTATVLKQ GSNQAIRFYV MTSLRNWYKG DDPCREMHPL VTAVFGAAAG
AASVLGNTPL DVVKTRMQGL EAHRYRSTVD CAYQILRNEG PQAFYKGTVP RLGRVCLDVA
IVFVIYEEVV KLLNGVWKTD
//
