ID W5MIP4_LEPOC Unreviewed; 2102 AA.
AC W5MIP4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0000259|PROSITE:PS50067};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008253.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008253.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; AHAT01005177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000008253; -.
DR Ensembl; ENSLOCT00000008263.1; ENSLOCP00000008253.1; ENSLOCG00000006812.1.
DR eggNOG; KOG0242; Eukaryota.
DR GeneTree; ENSGT00940000160597; -.
DR HOGENOM; CLU_232538_0_0_1; -.
DR InParanoid; W5MIP4; -.
DR Proteomes; UP000018468; Linkage group LG20.
DR Bgee; ENSLOCG00000006812; Expressed in embryo and 11 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01374; KISc_CENP_E; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF36; CENTROMERE-ASSOCIATED PROTEIN E; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 6..335
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1245..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2071..2102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 351..406
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 661..780
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 806..833
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 857..891
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1376..1542
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1726..1771
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1801..1895
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1958..2006
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 89..96
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 2102 AA; 240754 MW; 2B937763AD781DDF CRC64;
MAGESAVKVC VRVRPLIQRE EAEVSNVESV PIYWKTDQQT VYQVDGPKTF SFDRVFNVNE
STSQVYDEVA KPLVISAIKG YNGTIFAYGQ TSSGKTFTMM GSNESLGVIP LAIHDIFETI
AQSQNMEFLL RVSYMEIYNE TVTDLLVDST KRKPLEIREG INRTVYVADL TEEVVVSASQ
VLEWIKKGEK NRHYGDTKMN QRSSRSHTIF RMILESRERS DPSSGEIADQ AVMVSHLNLV
DLAGSERASQ TGAEGLRLKE GCNINRSLFT LGQVIKKLTD GNGGGFTNYR DSKLTRILQN
SLGGNAKTVI ICTITPATVE ETLSTLQFAS TAKHMKNDPH VNEVLDDGAL MRRYRNEIVD
LKRRLEEVSS ETRMQATEKE VLAQLLQEKD QLQKEQEDRI RNLTKIVITS SSFAINDIRS
KRRMTWGGKL LRGRQSEGFH FGDIGFLEHA TKRKKSDLSA LIEPDDNIEG EDVWQHNIED
FPFDVEMNMS NVSVRRSRVV QSTVSDVSAS TPNRKSACKL LNIIARNLIS SERMCLNNAQ
FQYFQLDLRG VYLLFVSFGG VLRVDLPKIQ LSEVKERIAG LEEELQKKIR ETWEAVEKQN
AAEKRVSELE EALKAQDPRG EGSHVEGCRE ALCKMASSYR RHRLRQPVQY EKDFRDTIQL
CETLVAEKEE LSAKLNLLKE ELDALWKEKE GLQQEKVRLQ QEIIEKEEQH EFNILEQEVH
KQSETELAKE ITSLKMELEN SENDMAARYK QMEVEVNQLR SQLESEKMRF KRMETDLQKE
LLMAFEENAK LNTLLDGKVP KNLIERLDLE KSVAELKKEL EKSQEGERAL QTEVNSLSAL
KNLPDKVDDL MKQVHIYNQV TEDLRETQTK LSEADQKMAN LSEQHSAVQA QYVEVAEDCE
KLKTELESSS IEKQQCLNGM EDLKLQVRSQ VLRKQQSSIA KNKNKSTFQV LNVSEELQLV
SSERDSLLFE KGDSTQRTEA DLQELRTHVA SLTQEREQLQ EILESVRAEK SQLKADLEEK
XPFMNVCENR SYRKLLLKAV KNQEELRQQQ QQQLMTDLQT ESAEREAQLE QQLRDLNEQL
RLVSSERDSL LSERRDSAHR PEAELEEMRS HITSLTQERE QLQETLESVR AEKSRLQAEL
EENVEMAVES QAELQKQQQL MADFRSQSAE QLTQLEQQEI LESVRAEKQQ LKADLEENVE
MSVETQEELR QQQQLMTDLK IQTAEKEARL QQQITELSEK LKLVSSERDS LPSERRDSAH
RPEAELEEMR SHIDSLTQER EQLQEILESV RAEKSQLKAE LEEKMVETQE ELRQQQQLIS
DLKTQREERE TQLEQQAVET QAELCRAQDE LRTQQELISD LKTQRTKRET QLDLKVNELS
EQLQLVNSER DSLLLEKRDS TQRTESDLQE LRTHIDSLTQ EREQLQETLE SVRAEKSQLN
SLEDAVSKQL QIELHQVQDE LNKKEQEAEE LKGLVADKEV QLNSMQESLS AKLVQGQERA
LEERDCSLAE LQGKVAALAQ ERQQLRGSLE HLREQLESQT EQHQAVSHPC PRPQFTNTPR
YNLKKQEWLL LTCFSFPEQS KSMLKLNSGI SKINTDLVLR LRQQAVSIAE IHKDHFEAAL
QHSIASFEER KLHDLLIQRI QRASGSSSEH VSQQAQRVSD LLEERQRRVQ EMTEILAELE
DGLSCHATSR AQEHPIQEEI NRTLKALCAA PTAGFVELEQ VLQKENTRMT EKLQQTTRVL
EGLKAKYYDI KERCQALLAK STAELKEQRD RSQTLLVELD DGSPKKGSEV LQENLLLLER
LETMQLKIKK LEGSLADAEA KAADRKRAAD GMQMELQKLV AQVKERDESI STLRRSLSEL
EKRAEKGASP YIEELETLRS KLVKMEMERT GLLKKQEQTV AAMTAALEHR DESLRKLKET
LRKSQQDQEA SFVADEKPHT KAPVTCGGGS GIVQSTMMLM IKAEKAKLEA EVHQQKKKIG
QMESVVSSLQ AEASKWKGRA RKLKETSGLK GSLSEMETLC DNQPNVSPRT PTKRRQVTSE
GFILDSPKSK FFDSRSGSLS VACPKQFFDN STLGTIPAEP NSEGDWWSLA PQKDGAENCK
TQ
//
