ID W5MJJ2_LEPOC Unreviewed; 3509 AA.
AC W5MJJ2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=WD repeat and FYVE domain containing 3 {ECO:0000313|Ensembl:ENSLOCP00000008551.1};
GN Name=WDFY3 {ECO:0000313|Ensembl:ENSLOCP00000008551.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008551.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008551.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01014562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01014563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01014564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01014565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01014566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01014567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01014568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000008551; -.
DR Ensembl; ENSLOCT00000008561.1; ENSLOCP00000008551.1; ENSLOCG00000007056.1.
DR eggNOG; KOG1786; Eukaryota.
DR eggNOG; KOG1788; Eukaryota.
DR GeneTree; ENSGT00940000155680; -.
DR HOGENOM; CLU_000175_5_0_1; -.
DR InParanoid; W5MJJ2; -.
DR OMA; GVCHLIE; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000007056; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035973; P:aggrephagy; IBA:GO_Central.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2500..2625
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2652..2945
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3092..3133
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3438..3498
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 2420..2491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3246..3308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2430..2447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3267..3300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3509 AA; 392701 MW; 1CF5EF435BFD8C71 CRC64;
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFSELCHPPR HMTQKEQEEK LYMMLPVFNR
VFGNAPPSTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEVNQSEEA
SRGWMLLTTI NLLASSGQKT VDCMTTMSVP STLVKCLYLF FDLPHVPEAP GAAQTELPLA
DRRALLQKVF VQILVKLCSF VSPAEELAQK DDLQLLFSAI TSWCPPHNLP WRKSAGEVLM
TISRHGLSVN VVKYIHEKEC LATCIQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL
LDDFRMCQGY TFLCDLMLRL EQAKEDDSKD ALKDLVNLVT SLTTYGVNEL KPAGLTTGAP
FLLPGFVVPQ PSGKGHAVRN IQAFSVLQNA FLKAKTSRLS QIILDAISNI YVADNANYFI
LESQHTLSQF AEKISKQLEV QGKYFELLEF VVFSLNYIPC KELFSVSVLL KSSTSYQCSI
TAVRTLLKFS RHDPIFGDVF REVGLLEVMV NLLHKYAALL KDPTQAFNEQ GDSKNNSLME
DQKQLAWLVM ETLTVLLQGS NTNAGVFREF GGARCVHNIV KYPQCREHAL MIIQQLVLSP
SGDDDMGTLL GLMHSAPCTE LQLKTDILKA LLAVLRESHR TRTVFRKVGG FVYVTSLLVA
MERSLCCPPK NGWEKVIQNQ VFELLHTVFC TLTAAMRYEP ANSHFFRTEI QYEKLADAVR
LLGCFSDSKK IGLATVVPSN SQPFQRLLED DVIPVDSVCP TLRHCSKLFI FLYKMATDSF
DSRAEQVPPC LTHETSLPSP WGTPALSRKR HGYHGVSAPT SSLSMKAVTD LKLHLGAPPL
HSPDAVIIHP GAGLAMLDLL ASVTSEMQPE HALDLQLAIA NILQLLVHSE RNQQIMCEAG
LHSRLLQRCS CALSDEDHPL HPPLQRMFER LASQALQPMV LREFLRLGNP LNCGAWDKKL
LKQYRVHKPS SLSYEAEMRN SMTMSMEGFG PDSVFTVNED NSQYRISRSL VRSAEGSTVP
LTRVKCLVSM TTPHDIRLHG SSVTPGFVEF DTSLEGFGCL FLPSLAPHNA PSSNVNASGV
NDGAVVSGIG NGERLFPPPS GLTYSSWFCI ERFSSPPHNH PVRLITVVRR ATSSEQHYIC
LAIVLSAKDR SLIVSTKEEL LQNYVDDFSE ESSFYEILPC CARFRCGDLI SEGQWHHLVL
VMSKGMLKNS AATLYIDGQL VNTVKLHYVH STPGGSGSAN PPVVSTVYSY IGTPPAQRQL
STLVWRLGPT HFLEEVLPAS SVSTIYELGP NYVGSFQAVC LPCKDSKAEA AASSPVALVP
EEKVSFGLYA LSVSSLTVAK IRKVYNKLDS KAIAKQLAVS SHENATPVKL LHNSAGHLNG
PARTIGAAVI GYLGVRAFVP KPVATNLQYI GGAAAILGLV AMASDVEGLY AAVKALVCVV
KSNPLASKEM ERIKGYQLLA MLLKKKRSLL NSHILHLTFS LVGTVDSGHE TSIIPNSTAF
QDLLCDFEVW LHAPYELHLS LFEHFIELLT ESSEAAKNAK LMREFQLIPK LLLTLRDTSL
SQPTIAAISN VLSLLLQGFP NSYDLLRFGQ FISSTLPTFA VCEKFVVMEV NNEEKIDGGN
EDDFGGLLSA SLILLRNRLL DILLKLLFIC KEKSTVNIQA CEELVKTLGF DWLLMFMEEH
LHSTTVTAAM RILVVLLSNQ TILSRFKEGL SGGGWLDQTD SVLTNKIGTV LGFNVGRSAG
GRSTVREINR DACHFPGFPV LQTFLPKHTN VPDLYFLLMA LFLQQPVTEL PENLQFDLDS
IWTFIFGVPA SSGAVVGSIH NVCTEAAFLL LAMLRSMLNL PWQSEEEGSW LREYPVTLMQ
FFRYLYHNVP DLAPMWISPE FLCALAATVF PFNIRPYSEM VSDLDDEVGS PAEEFKAFAV
DTGMNRSQSE YCNVGSKTYL TNHPAKKYVF DFMRVLIMEN LCMTPASKQT PIIDLLLEAS
PERSTRTQQK EFQSYILDSV MEHLLAADVL LGEDASLPIT SGGSYHVLVN NVFYFTQRVV
DKLWQGMFNK ESKLVVEFII QLIGQSKRRS QGLSLDPIYH CLNRTILYQL SRPHKTVPQQ
VALLDALRVL TVNRNLILGP GNHDQEFIAC LAHCFINLHV GSVDGFGLEA EARMTTWHIM
MPSDIEPDGP HSQDVSEGRQ LLLKAVNRVW TELILSKKQA LEEIFKVPLP VNDRGHVDIV
TARAHIEEAA AKSWQNHLAH EKKSISRGEA IAPVSQSKLS RVSSGFGLSK LTGARRNRKE
SGLNKSNLSA QETFQWMFTH IAVVRDLVAM QYKEYQERQQ NALKYVTEEW AQIEYELLRE
RGLWGPPIGS HLDKFLLEMT EGPCRMRKKM VRNDMFYIHY PYVPDTEQDT SSQKPTRYRR
AISYDSKEYY MRVLSGNPGM YQHSIEQSSE GETTQHEPEH GEDTIAKVKG LVKPPLKRSR
STADGADEDS QEQLQDQLLE SGAMDEEEKT DNTTLLRLLE EGEKIQHMYR CARVQGLDTS
EGLLLFGKEH FYVIDGFTMT ITREIRDIET LPPNMHEPII PRGARQGQSQ LKRTCSIFAY
EDIKEVHKRR YLLQPIAVEV FSGDGRNYLL AFQKGVRNKV YQRFLAVVPS LADSSESVSG
QRPNTSVEQG SGLLSTLVGE KSVTQRWERG EISNFQYLMH LNTLAGRSYN DLMQYPVFPW
ILADYDSEEL DLTNPKTFRN LAKPMGAQTD DRLLQYKKRF KDWEDPNGET PAYHYGTHYS
SAMIVASYLV RMEPFTQIFL RLQGGHFDLA DRMFHSVREA WLSASKHNMA DVKELIPEFF
YLPEFLLNSN NFDLGSKQNG IKLGDVILPP WAKGDPREFI RVHREALECD YVSAHLHEWI
DLIFGFKQQG PPAVEAVNVF HHLFYEGQVD IYNINDPLKE TATIGFINNF GQIPKQLFKK
PHPPKRVRSK SNGEIPGIPA SLSSAGDKIF FHHLDNLRPS LAPVKELKEP VGQIVCTDKG
ILAVEQNKVL IPPAWNKTFA WGYADLSCRL ANYESDKAAI VYECLSEWGQ ILCAICPNPK
LVITGGTSTA ICVWEMGTSK EKAKTLTLKQ ALLGHTDAVT CLTASSAYHI IVSGSRDRTC
IIWDLNKLAF VTQLRGHRAP VSALCINELT GDIVSSGGTY IHVWSINGSP IVSVNTFTGR
SQQILCCCVS EMNEWDTQNV IVTGHSDGVV RFWRMEFLQV PETPAPEPVE IPDVPDCCAE
DKIEGQVAHD DDSSDSDGDD QSTSQEAKPR VTHSQQGSAI HRPKSSVNRP GTSWSADSGS
DDSRRWSDTL SLDEKDGFVF VNYSEGQTRF PVQAHPQPIP QSSIHPQPSA LAHGPVEPRH
YNKLRPGYRW ERQLVFRSKL TMHTAFDRKD NAHPAEITSL GISKDHSKIL VGDGRGRVFS
WSVSDQPGRS AADHWVKDEV VDSCSGCTVR FSLTERRHHC RNCGQLFCQK CSRFQSEIKR
LKISSPVRVC QNCYYNLQHE RGSEEGCRN
//
