ID W5MJP4_LEPOC Unreviewed; 264 AA.
AC W5MJP4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Homeobox protein {ECO:0000256|PIRNR:PIRNR037109};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008603.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263, ECO:0000256|PIRNR:PIRNR037109}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037109, ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317, ECO:0000256|PIRNR:PIRNR037109}.
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DR EMBL; AHAT01020101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006636640.1; XM_006636577.2.
DR AlphaFoldDB; W5MJP4; -.
DR STRING; 7918.ENSLOCP00000008603; -.
DR Ensembl; ENSLOCT00000008613.1; ENSLOCP00000008603.1; ENSLOCG00000007106.1.
DR GeneID; 102685462; -.
DR KEGG; loc:102685462; -.
DR CTD; 30350; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000160866; -.
DR HOGENOM; CLU_071854_0_0_1; -.
DR InParanoid; W5MJP4; -.
DR OMA; PERTECA; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000018468; Linkage group LG12.
DR Bgee; ENSLOCG00000007106; Expressed in mesonephros and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:UniProtKB-UniRule.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0009954; P:proximal/distal pattern formation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR PANTHER; PTHR45970; AGAP004664-PA; 1.
DR PANTHER; PTHR45970:SF4; HOMEOBOX PROTEIN HOX-D9; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|PIRNR:PIRNR037109};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037109};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037109};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|PIRNR:PIRNR037109};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR037109}.
FT DOMAIN 194..254
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 196..255
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 111..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 29883 MW; 1BD47C01740CA59C CRC64;
MSTTGTLSNY YVDSIIGHEA EDVYGARFVQ GAHSTTSRPS GVADNADFSS CSFAPKSAVF
PTSWSSVHPQ STAAVSGIYH PYVHQSHLAA TDGRYVRSWI EPLSNSVSFS GFHPNPRHYG
TKPESLPSKR TECSSFEAQT PTLPDFTSGA FSESKVKGTK EATGSDISNH SEPKEDKTQQ
LDPSNPAANW IHARSTRKKR CPYTKYQTLE LEKEFLYNMY LTRDRRYEVA RILNLTERQV
KIWFQNRRMK MKKMNREKGT KEQH
//
