ID W5MK58_LEPOC Unreviewed; 2443 AA.
AC W5MK58;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=CHD9 {ECO:0000313|Ensembl:ENSLOCP00000008767.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008767.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR EMBL; AHAT01020892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01020893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01020894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01020895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000008777.1; ENSLOCP00000008767.1; ENSLOCG00000007225.1.
DR GeneTree; ENSGT00940000155706; -.
DR HOGENOM; CLU_000315_5_1_1; -.
DR Proteomes; UP000018468; Linkage group LG23.
DR Bgee; ENSLOCG00000007225; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18668; CD1_tandem_CHD5-9_like; 1.
DR CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR CDD; cd18061; DEXHc_CHD9; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 3.40.5.120; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR PANTHER; PTHR46850:SF1; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR Pfam; PF07533; BRK; 2.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 2.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 2.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 315..381
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 414..588
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 728..884
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1573..1776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1849..1877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1932..1956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2262..2319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2373..2443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1742..1764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2275..2293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2417..2436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2443 AA; 271576 MW; 0A67CC5E0E7E8508 CRC64;
MSSVKRPRGR PPSSKNTNGS SGHTRVLSPQ LKSGTSSSSS SSSSSSEKRQ KKKPLMEQAL
EDKQEKANRI ISEAIAKARE RGEKNIPRVM SPESFPCSST PPRQDHKPHH AKAPPTDPPS
RKAKGPAASR SKQKTKIGKI VIKFGKKKKR KTESSEELSD TEPLPRRCSK DDDSKRRSNR
QVKRKKYAEE GECKVSDEEV KVIVKAKKTA SGSRKEQPVQ LFVENPSEED AAVVDKIMSS
RIGKKEVSPG VVVEVEEFYV KYKNYSYLHC EWATEQQLVK DKRIQQKIKR FKIKQAQRAH
FFADMEEEPF NPDYVEVDRV LEVSYCKDKD TGEPVVYYLV KWCSLPYEDS TWELKEDVDQ
SKIEEFEQLQ AARPDPRRVE RPPASMWKKT EQSREYRNGN RLRDYQLEGV NWLLFNWYNR
RNCILADEMG LGKTIQSITF LEEIFLTGIR GPFLIIAPLS TIANWEREFR TWTDLNVIVY
HGSMVSRQML QQYEMYFRDS QGRVIRGAYK FHAIVTTFEM ILGGCPELNA IEWRCVIIDE
AHRLKNKNCK LLEGFKLMSL EHKVLLTGTP LQNTVEELFS LLHFLEPLRF PSESTFMQEF
GDLKTEEQVQ KLQAILKPMM LRRLKEDVEK KLAPKEETII EVELTNIQKK YYRAILEKNF
SFLSKGAGQA NVPNLVNTMM ELRKCCNHPY LIKGAEEKIL EEFREVHNPA ALDFHLQAMV
QSAGKLVLID KLLPKMKAGG HKVLIFSQMV RCLDILEDYL IQRRYLYERI DGRVRGNLRQ
AAIDRFSKPD SDRFVFLLCT RAGGLGINLT AADTCIIFDS DWNPQNDLQA QARCHRIGQN
KAVKVYRLIT RNSYEREMFD RASLKLGLDK AVLQSMSGRE NSVGGIQQLS KKEIEDLLRR
GAYGAIMDEE DEGSKFCEED IDQILQRRTK TITIESEGRG STFAKASFVA SGNRTDISLD
DPNFWDKWAK KAEIDLDTIN GRNSLVIDTP RVRKQTRPFS ATKDELAELS EPESEGDDKP
KLRRPYDRLN GYGRTECFRV EKNLLVYGWG RWKDILLHGR FKRQLNEHDV EIICRALLAY
CLVHYRGDDK IKSFMWDLIA PTEDGQTKEL QNHLGLSAPV PRGRKGKKVK TQPSSFDIQK
AEWIRKHNPE HLLQDDGYKK HLKHHCNKVL LRVRMLYYLK QEVIGDQSQK VLDGVDSSET
EIWVPEPDHS ELPAHWWDTE ADKSLLIGVY KHGYEKYNTI RADPALIFLE RVGRPDDKAI
AAEQRANDFM DGDGDDPEYK PAPALLKDDI EDDASSPGDL VIADGGGEGG MLMEGDALYW
PPPSALTTRL RRLITAYQRN TKNRQIQHIQ QALPAQPSAL LSTLNDNINP KIAAKIERQQ
RWTRREEADF YRVVSTFGVV FDPEQGRFDW TKFRAMARLH KKTDDSLQKY LCAFTAMCRR
VCRLPPREGE SVDPSISIQP ITEERASRTL YRIELLRKVR EQVLRHPQLY ERLQLCQPGP
DLPVWWEPGA HDRDLLIGAA KHGVSRTDYH ILRDPELCFM TAQSNYSQNK GAQSRTPTPL
LLPQYQAMVA GSPLAAQPRP PDPRTAQVEE PRQRAEHLKE EPPTSEEEGA ERKGKAEQWS
PRSGAQTQGL VDSKAGGQVK GESERRSMVA ARTEPLTPNS VAKKQKRGSK RGRRQGRRAS
CTDSDTERSS SCSSSRSSSS SSSSSSSSSS CSRSGSSSSS SSSSCSSGSS SSSSSSSSSS
SEDSDSDRED RKASVAEAAK IKGFDEDSVA SLSTTQDETQ DSFLTDNGLH SSSHAFQGGY
MLAASYWPKD RVMINRLDSI CQAVLKGAWP AARRGYEGSA VSSFYTTKLL DSPSDQGGPP
GPREDPAQSP QMSKQEGSLK LTFQKQGLPQ KRPLEGEDGP LGQQQYLARL RELQSASDTS
LADFTKPLPT AAGAAGPVRA NGALDGQPVV KKRRGRRKNV EGMDLLFLNK NRSTPDHVGP
GVGGSAQASP AVVPGLGYGP SQAPVDTESR VPVINLKDGT RLAGDDAPKK KDLEQWLKEH
PGYVADVGAF IPGLNKMTFQ DGRPRQKRHR CRNPNKIDIN SLTGEERVQI INRRNARKVG
GAFAPPLKDL CRFLKENPEY GVPPEWADVV KRSGFLPESM FDRILTGPIV REEVSRRGRR
PKSEMAKAAA AAANASAATL SINPLLSNGL LSGMDLSSLQ ALQQNLQSLQ SLHLTAGLMG
LPGGLAAAGD ANNLAAMFPM MLSGMAGLPN LLGMGGLLGK PQEGAGVSED GTKKGNGGSG
DSSSSASKTP VPTDTKGERT EGQGADQCPS DPSTSGATAP LSASAVAAAA ASSNHPLALN
PLLLSSMLYP GMLLTPGLNL PISALSQSGV FDAQQQSTSA RPAATASGET PRGAGGSTPA
KGQEPGEQKE NSAEEGSEKA GSSSSESEGS SSSSEDSDSS NED
//
