ID W5MKD8_LEPOC Unreviewed; 605 AA.
AC W5MKD8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Thyroid hormone receptor interactor 10 {ECO:0000313|Ensembl:ENSLOCP00000008847.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008847.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008847.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01007692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01007693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01007694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01007695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MKD8; -.
DR STRING; 7918.ENSLOCP00000008847; -.
DR Ensembl; ENSLOCT00000008858.1; ENSLOCP00000008847.1; ENSLOCG00000007300.1.
DR eggNOG; KOG3565; Eukaryota.
DR GeneTree; ENSGT00950000183047; -.
DR InParanoid; W5MKD8; -.
DR OMA; CVAIYQF; -.
DR Proteomes; UP000018468; Linkage group LG6.
DR Bgee; ENSLOCG00000007300; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07653; F-BAR_CIP4-like; 1.
DR CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR CDD; cd11911; SH3_CIP4-like; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF17; CDC42-INTERACTING PROTEIN 4; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..263
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 403..480
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 538..599
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 291..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 410..437
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 330..358
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 69265 MW; 4315AF1E24ABA545 CRC64;
KDWVWGEDQY ETIEKHTQWG LDQVEKYVKF VKERTEIEQS YAKQLRSLTK KYIPKRGNKE
EQECRFSHYQ SFQDILTEMN DYAGQREVIA ENMMLNICVE VTKYLQEIKQ ERKTYLAEGR
KAQQILESSY KQLDSSKKRF EREWREAEKA SQYAEKTDQD INATKADVER AKTLAHARLH
VAEECKNDYA AQLQKYNREQ NQFYFSDMPQ IFNKLQEMDE RRIRKLAEGY NTFAETEKRV
MPIIGKCLDG IAKAAASTNE RNDSLTLIEM HKSGFERPGD LEFEDYSQGI NRASSDSSLG
TPKCPHDRPM SRNRNKLWPF TKKSKLSPPF LPSQLPPPPL TPFSNPPAPS PANGPPSPKF
SRDPLSYCLN EINKTVKPRI SSFRSLKRTN LSSKPTITED FAHLPPEQRR KKLQQKIDEL
NKELQKEVDQ SEALSKMKDV YEKNPQMGDP SSLAPQIAQT AHNMDRLRGE LQKYGSWLAE
AGGSSEGTRY SVTFNNNNGS HEKYSPDGAH SDGSNPDQTS QAVYAEFDDD FDDEDPVPPI
GKCTALYSFA GSSEGTISMT DGEIFSVVEE DKGDGWTRVR RANGDEGYIP TSYVKITLHR
KKAAE
//
