ID W5MLG2_LEPOC Unreviewed; 713 AA.
AC W5MLG2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=T-box transcription factor 3 {ECO:0000313|Ensembl:ENSLOCP00000009221.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009221.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000009221.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR EMBL; AHAT01005206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MLG2; -.
DR STRING; 7918.ENSLOCP00000009221; -.
DR Ensembl; ENSLOCT00000009232.1; ENSLOCP00000009221.1; ENSLOCG00000007598.1.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000158066; -.
DR HOGENOM; CLU_023038_1_0_1; -.
DR InParanoid; W5MLG2; -.
DR OMA; QGIAMSP; -.
DR Proteomes; UP000018468; Linkage group LG20.
DR Bgee; ENSLOCG00000007598; Expressed in intestine and 10 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20188; T-box_TBX2_3-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR048387; TBX2_3_RD.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF91; T-BOX TRANSCRIPTION FACTOR TBX3; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR Pfam; PF20627; TBX2-3_RD; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 108..286
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 302..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 77514 MW; C1D7F88A5F7DD860 CRC64;
VSLPMRDPVV PGTSMAYHPF LPHRAPDFAM SAMLGHQPPF FPALALPPNG ALSLPGALGK
PIMDQLVGAA ETGLHFSSIG HQAAAAHLRP LKTLEPEEEV EDDPKVHLEA KELWEQFHKR
GTEMVITKSG RRMFPPFKVR CTGLDKKAKY ILLMDIVAAD DCRYKFHNSR WMVAGKADPE
MPKRMYIHPD SPATGEQWMS KVVNFHKLKL TNNISDKHGF TILNSMHKYQ PRFHIVRAND
ILKLPYSTFR TYVFPETEFI AVTAYQNDKI TQLKIDNNPF AKGFRDTGNG RREKRKQLAL
QSMRSYEEQK KDTGTSDESS GEQAAFKRFG QALSPAVSAV GPSNLKNACE SDEDSDEESK
DENPQDGQES NKISTTTEEG KDTDRSPTKA HLFASSDSAS RARTEDPART DKSPADSRQS
PVTIISSTTR SLSGEDLKPS IRDPSKQDEC RPMSKENYVP LTVQTDSSAH MSQGHLHNFG
FPPGLAGQQF FNPLGGAHPF LLHPSQFNMG GAFSNMAAAG MGPLLAAVSS AGVSTMDTAS
IASPQGLTGA SGLPFHLQQH VLASQGLAMS PFGSLFPYPY TYMAAAAAAS SAAASSSVHR
HPFLNAVRPR LRYSPYSIPM SIPDSSTLLT TALPTMSNSA IEIKANSMAT SPVSATMDST
SEVNGRSSTI SSGSVSLSPK TCPEKDSTNE LQSIQRLVSG LDSKQDRARS VSP
//