ID W5MLP8_LEPOC Unreviewed; 539 AA.
AC W5MLP8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Nuclear receptor subfamily 5 group A member 2 {ECO:0000313|Ensembl:ENSLOCP00000009307.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009307.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000009307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC subfamily. {ECO:0000256|ARBA:ARBA00007536}.
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DR EMBL; AHAT01016050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006634936.2; XM_006634873.2.
DR AlphaFoldDB; W5MLP8; -.
DR STRING; 7918.ENSLOCP00000009307; -.
DR Ensembl; ENSLOCT00000009318.1; ENSLOCP00000009307.1; ENSLOCG00000007670.1.
DR GeneID; 102684805; -.
DR KEGG; loc:102684805; -.
DR CTD; 2494; -.
DR eggNOG; KOG4218; Eukaryota.
DR GeneTree; ENSGT00940000153391; -.
DR HOGENOM; CLU_011437_0_0_1; -.
DR InParanoid; W5MLP8; -.
DR OMA; DNMQVSQ; -.
DR OrthoDB; 2968690at2759; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000007670; Expressed in intestine and 8 other cell types or tissues.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0061017; P:hepatoblast differentiation; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd07167; NR_DBD_Lrh-1_like; 1.
DR CDD; cd07069; NR_LBD_Lrh-1; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5-like.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24086:SF49; NR5A2 PROTEIN; 1.
DR PANTHER; PTHR24086; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 81..156
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 298..537
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 419..422
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 514
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 518
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
SQ SEQUENCE 539 AA; 61030 MW; 94E85FEC8B80FEF8 CRC64;
MSSSPEPGMG QDFTRQELSG LGGLSDGAEP PVPLCSAVML PKVETESLGL ARSHGEQGHM
PENMQAPQFK MMDYSYDEDL DELCPVCGDK VSGYHYGLLT CESCKGFFKR TVQNNKRYTC
IENQSCQIDK TQRKRCPYCR FQKCLTVGMK LEAVRADRMR GGRNKFGPMY KRDRALKQQK
KALIRANGLK IEAMTQVMQT VPTDLTISSA IQNIHSASKG LPLSHTALPP ADYDRSPFVT
SPISMTMPPH GSLQSYQAYS HFQSRTIKSE YPDPYTSSPE SLMGYSYMDT YQTSSPPSFP
HLIVELLKCE PDEPQVQAKI LAYLQQEQAS RGKHEKLNTF GLMCKMADQT LFSIVEWARS
SIFFRELKVD DQMKLLQNCW SELLILDHIF RQVVHGKEGS VLLVTGQQVD YSIIASQAGA
TLNNLMSHAQ ELVGKLRSLQ FDQREFVCLK FLVLFSLDVK NLENFHLVES VQEQVNAALL
DYIMCNYPQQ TDKFGQLLLR LPEIRAISMQ AEEYLYYKHL NGDVPCNNLL IEMLHAKRA
//