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Database: UniProt
Entry: W5MLQ7_LEPOC
LinkDB: W5MLQ7_LEPOC
Original site: W5MLQ7_LEPOC 
ID   W5MLQ7_LEPOC            Unreviewed;      1488 AA.
AC   W5MLQ7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   05-JUN-2019, entry version 40.
DE   SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSLOCP00000009316};
GN   Name=ARAP1 {ECO:0000313|Ensembl:ENSLOCP00000009316};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009316, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000009316, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000009316}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AHAT01003027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7918.ENSLOCP00000009316; -.
DR   Ensembl; ENSLOCT00000009327; ENSLOCP00000009316; ENSLOCG00000007666.
DR   GeneTree; ENSGT00940000157424; -.
DR   OMA; WVKSIAK; -.
DR   Proteomes; UP000018468; Linkage group LG3.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 4.
DR   Gene3D; 3.30.40.160; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 3.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 4.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   GTPase activation {ECO:0000256|SAAS:SAAS01175775};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN        5     69       SAM. {ECO:0000259|PROSITE:PS50105}.
FT   DOMAIN      383    475       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      489    578       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      584    698       Arf-GAP. {ECO:0000259|PROSITE:PS50115}.
FT   DOMAIN      792    899       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN     1010   1186       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   DOMAIN     1219   1308       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN     1321   1432       PH. {ECO:0000259|PROSITE:PS50003}.
FT   REGION      113    149       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W5MLQ7}.
FT   REGION      208    301       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W5MLQ7}.
FT   REGION      356    377       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W5MLQ7}.
FT   COMPBIAS    117    144       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                W5MLQ7}.
FT   COMPBIAS    208    229       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                W5MLQ7}.
SQ   SEQUENCE   1488 AA;  168836 MW;  A355FD34CF42AAB6 CRC64;
     MSSGVTPHSV SEWLTVLHLE QYVKAFEGEG YDLISECRGL TAGDLEQVGV VLPGHQKRIL
     ASLQKIFSVA QEGEKPLPMP RKIYRLPNAR NDQKDVLSPD PPEVGSPRFM DSSILGKGPP
     PIPPRVTPNR PPLRFTPAVA PTPYPRPDTL ALNTAALEQQ PLPKKSSPSP VSEQCHLYEQ
     CSSPGQTDKL VPPLPAKRYA VSVPKEALEV PPPLPRRPPV PPPREISPRA SPPANQSPVD
     DPSEVDKVPD VPPRNKFSQQ PVVLPLPPQR RPPKLPNISS LSTDSSEDYE DPDIQNPYLC
     DPIDMTDKEE RLAVPRLEKR RFNSLCSDDE QLDEEDSYET ILQEVCLQDY GLSTLKETRH
     PPPMGRRPSA GVKDGNDMSQ LTPVIKMGWL DKNPPQGSLI YQKRWVKLDA DYLRYFDSDK
     DMYSKRIIPT ASITHIANVG DQKFEVVTHN RTFVFRAESD LERKEWVTVL QETIRDQRAT
     NKDLSSSPPA EMESYLELRG LRSKLYVVVS GEKVFLYKNM DDYKLGIGIT SIDMNVGNVK
     DTDRRSFDLT TPYRIFSFVA ESDVQKEEWV EAMQNSIGEA LSNYEVAKKI WAEESNGFCA
     DCGAAKPEWA AINLCVVFCK RCAGEHRGLG PSISKVRSLK MDKKVWIDDL IKLFSVLGNQ
     RANSFWAANV PPSEALSPAS CSEERRKFIA AKYREGKYRR YHQLFGNQEA LDNALCINVQ
     SDDVLETLSL VFCGANVNCD TGNPDFPTPI SLAQSYDQKL QVEFLTQNRN TEIPRSEVGG
     HMDTVHYMAP PSITHNGFLY KTASMGKPIT ERKAKEEFSR RWCTLNDGNF SYYDSDRNST
     PNGELKMKDV ACLVVNPPEK HGYDYTFEIY TELERLYLFG TDNSEHMREW VKSIAKSFIP
     SSAEDLLNWD FERIGKLQYK DGLNLQSAKT GWFALVGSTL HACFEDSEGE EAIHLKKLQE
     LSIQQENEVL VLVERRRTLY IQGDRKLDFL GWSTAIQRAA GSSGDTLSQQ QLTESDIPVI
     VDRCIDYITQ CGLTSEGIYR KSGVNSKIAS LLESFRKDAR SVRLKEGEHQ VDDVSNVLKR
     FFRDVKEGIF TSGAAVEWLN TPAVADESQK ILLYQSLLNN LPRVNKATLK SLVNHLYCVQ
     RFADMNQMNL HNLAIVFGPT LFQTDGKDYN AGRVIEELIG LYVAIFNVNE QQLKKQLDEI
     TAIIKLREIN SSSKAQHAGD FICTVYLEEK KETAEQHVKI PATMTAAELA FEILDRRKIA
     VRDKDYWCCF EVNEKEETER PLHYQEKVLP ILHSMGTESC VVVKKHFSME AMLIYLASKV
     DDSKHGMMKF REERNLLGLG LNTGSFHDRY FILSSTTLRL YKEVRSHRPE KEWAVKSLKV
     YQGIKKKLRP PTCWGLTVVY QNEKQEKQQW YLCCDTQTEM REWFATFMSI QNDGNMWPSE
     SVKMRASRVQ LDTRLGNRSL IPLRGSENEM RNSVAAFTAD PLALFRNV
//
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