ID W5MM62_LEPOC Unreviewed; 405 AA.
AC W5MM62;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009471.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000009471.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; AHAT01032562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01032563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006629487.1; XM_006629424.2.
DR AlphaFoldDB; W5MM62; -.
DR STRING; 7918.ENSLOCP00000009471; -.
DR Ensembl; ENSLOCT00000009482.1; ENSLOCP00000009471.1; ENSLOCG00000007804.1.
DR GeneID; 102694406; -.
DR KEGG; loc:102694406; -.
DR CTD; 7480; -.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000160653; -.
DR HOGENOM; CLU_033039_1_3_1; -.
DR InParanoid; W5MM62; -.
DR OMA; FVECDDC; -.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000007804; Expressed in zone of skin and 4 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013302; Wnt10.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF76; PROTEIN WNT-10B; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01893; WNT10PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..405
FT /note="Protein Wnt"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866302"
SQ SEQUENCE 405 AA; 45267 MW; DE223A7053A89F9F CRC64;
MGIPHGLSWG RVLILAGLLR SPACTVLGND ILGLKVPRDP VLTPNTVCLA LPGLSKRQMS
LCVRSPDVTA SALQGIRIAL HECRHQLRDQ RWNCSSLESQ GKLPHQSAIL RRGFRESAFT
LSLLAAGVAH SVASACSLGK LRGCGCEAKR RLDDDKIRLK LTQLQLQTLQ RTPGLRGPQP
ASHVPLHPSA LLSPLPEDAP SLQDTWEWGG CSHDTRFGER FSRDWLDSRE SPRDIHARMK
IHNNRVGRQV VTDNMKRKCK CHGTSGSCQF KTCWYVTPEF RLVGALLREK FHSAVFINSQ
NKNTGVFNPW ARGAGGRRRV SRELVYFEKS PDFCEREPAL DSLGTQGRIC NKSSGGMDSC
SSLCCGRGHN ILKQTRSERC HCRFHWCCYV MCEECRVTEW VNVCK
//
