ID W5MMC4_LEPOC Unreviewed; 727 AA.
AC W5MMC4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009533.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000009533.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
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DR EMBL; AHAT01027070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006634198.1; XM_006634135.2.
DR AlphaFoldDB; W5MMC4; -.
DR STRING; 7918.ENSLOCP00000009533; -.
DR Ensembl; ENSLOCT00000009544.1; ENSLOCP00000009533.1; ENSLOCG00000007854.1.
DR GeneID; 102686763; -.
DR KEGG; loc:102686763; -.
DR CTD; 219972; -.
DR eggNOG; ENOG502QRKR; Eukaryota.
DR GeneTree; ENSGT00390000008048; -.
DR HOGENOM; CLU_023578_1_0_1; -.
DR InParanoid; W5MMC4; -.
DR OMA; QTHEEGY; -.
DR OrthoDB; 4221421at2759; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000007854; Expressed in camera-type eye and 12 other cell types or tissues.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..727
FT /note="Macrophage-expressed gene 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866324"
FT TRANSMEM 657..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..351
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 687..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 78354 MW; 53D95648F0CAE7A1 CRC64;
MAPTFRAWLQ SALTLLAMTF PRSCSSLPVS QRSGSGIQEC RKTLAMPVLE VLPGGGWDNL
RNLDMGRVMN VSYALCQTTE DGAYLIPDEV FVVPQKVSNV ETHSELIESW LQQSSSVARS
INADVSFLGV LNGKFSAESQ RMKTHQVRES SVTTRVQVRN FMYSVKAHPG FSFDSRFRQQ
AGEIAEALEN NQTRRAAFLA EMLVLQYGTH VLTAVDAGAS LVQEDYLRSS FLSSSQSEGF
SFSAAVGLNF FNKVNVGLHG GGKDTDSLTK AYQGNVTYSV TQSHGGAPFY PGITLQKWQE
STANNLVAID RSGLPLHSVL NPATLPDLPA PSVRKLARAV RDAVRRYYTV NTHPGCVKPD
SPNFNFQANV DDDSCEGPAT NLSFGGVYQR CAPLSPDAGP LCRVLEQKNP QTGSLGCQQP
YSPTLLRSEV REESYSRLEC RRECQRCWLI LSCCEQVCGD AYRVRRAQID TYWCATEGPA
PPLSGFLFGG LYGPSQQNPF TNSQACPPGF LALTLLSDGL KICQSADYEV GARFAVDFGG
LFSCEAGNPL AAGRPRCPAG FSQHVAAVSD GCQVLYCVRS GVFNGGELLP VRLPPFTRPP
LAGLGATNTV AVMMEGERSW IRDGQSRLWK VASPGQLQKM AEVFDGSPRG LSGGETFGVV
LGAAVALALA AGAVAYGLKR RRRWGRGSQR GYDQIPSEQA HGAAGPDEVA ETEMEGGGSG
STQPLLA
//
