ID W5MMT0_LEPOC Unreviewed; 671 AA.
AC W5MMT0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009689.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000009689.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR EMBL; AHAT01003022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006628207.2; XM_006628144.2.
DR AlphaFoldDB; W5MMT0; -.
DR STRING; 7918.ENSLOCP00000009689; -.
DR Ensembl; ENSLOCT00000009700.1; ENSLOCP00000009689.1; ENSLOCG00000007970.1.
DR GeneID; 102692470; -.
DR KEGG; loc:102692470; -.
DR CTD; 6534; -.
DR eggNOG; KOG3660; Eukaryota.
DR GeneTree; ENSGT00940000165269; -.
DR HOGENOM; CLU_006855_9_5_1; -.
DR InParanoid; W5MMT0; -.
DR OMA; IYIFLEM; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000007970; Expressed in zone of skin and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015193; F:L-proline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR PANTHER; PTHR11616:SF322; TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..82
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 74784 MW; 4B1BB18A8B13E4FE CRC64;
MKPLPEQWND HPKKSLDPLA GEMREKEPKQ TPGNDTEKTT ASRPQSPVLL NGVSLVHDVV
DPSSQPQFES RPPSPFPPPD LQPPREQWGG KYEFLLSCIG YCVGLGNVWR FPYLCYRNGG
GVFLIPYFIM LLFTGVPLFL MELSLGQYGA AGPITVWKCC PLLKGIGIGM LCVSTLVCLY
YNVIIAWTFY YLGMSFQSPL PWSCDAISNA GLCGNETSVN GTRNGSTLSA TEVFWNEQVL
GVSNSEGLHD PGPVRWQLAI CLLVAWFIIF LCMLKGIRSS GKVVYVTATF PYFVLIVLII
RGATLEGSLQ GVAFYLTPDW ERLASAQVWN DAASQIFYSL GIGVGGLLSM ASYNKFDNNV
IRDTLVITIG NCSTSFFAGF AIFSILGHMA WRKNVPVGKV ADTGPGLAFV AYPEALALLP
GSVFWSILFF LMLFMLGVDT LFGNMEGITT AILDEFPKLR GSVKYKTLFL AALCFGFYLM
GLLLITDGGI YWFTLIDSFS TSFGLIIITL FMCIGISFFY GVNQFCQDII DMICRCPPWC
SKVLFYFKAC WVFCTPFLLL FILTYIFIEM YNTPLHYGDY LYPRWGKALG VCMGAACCFQ
IPIWAVVAIA KESGTLRDRF RKAIRPLNSW RVNNLNTGQR VMPEMVEAPF TVNLTDADFT
AQTWERRTSE A
//
