ID W5MN39_LEPOC Unreviewed; 602 AA.
AC W5MN39;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Growth hormone receptor {ECO:0000313|Ensembl:ENSLOCP00000009798.1};
GN Name=GHR {ECO:0000313|Ensembl:ENSLOCP00000009798.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009798.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000009798.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01002707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MN39; -.
DR STRING; 7918.ENSLOCP00000009798; -.
DR Ensembl; ENSLOCT00000009809.1; ENSLOCP00000009798.1; ENSLOCG00000008056.1.
DR eggNOG; KOG3555; Eukaryota.
DR GeneTree; ENSGT00940000159987; -.
DR HOGENOM; CLU_022322_0_0_1; -.
DR InParanoid; W5MN39; -.
DR OMA; YKPQLYN; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000008056; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0070195; C:growth hormone receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
DR GO; GO:0004903; F:growth hormone receptor activity; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR025871; GHBP.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF108; GROWTH HORMONE RECEPTOR; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR Pfam; PF12772; GHBP; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..602
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866282"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..240
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 409..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 67397 MW; 406528DC6DB3882E CRC64;
ILVSFSSSLW VLTLILGKVL VSCYYCSHYC EIPARGPHFT GCRSREQETF RCWWSPGSYQ
NLTEPGALRV FFQKRDKEWK EWKECPDYSS STENECYFDK NYTSIWTSYC IQLRSRTQDV
TYDEQCFTVE DIVYPDPPIG LNWTLLNVSL TGQHFDILIR WESPPSADVK SGWMSLVYEA
QYRVVNVSEW IVMDIEKHTY QSIYGLKTNT EYEVRVRCRM PAFDNFGEFS DPITVYIPQI
PTKESTFPVA FVFIFGAVGV AILLMLIVFS QQQRLMVIFL PPVPVPKIKG IDPELLKKGK
LDELNSIFTN HHTYKPELYT EDLWVEFIEL DIDEPGEKME RSSTHKLLDL AQLNNTNALS
IKDDDSGRAS CYDPELPDTE AVPFSLTQLE ALGENAGLLE SESHAAVPRL SPSNYSAPES
SHPAALPAAS RAEGRPVIQT QLSNQSWVNM DFYAQVSDIT PAGGVLLSPG QQCKAEKASE
KENPLKDKKC QFAMVPVSAY TSETDAKQIG AIPSRDEHER SREKGFAQES CSSAESQPVE
PQGPCGAADS SVASPPCLSD YTLVQAVDSQ QSLLLNPTVV PTGARPVPVG YFSPDLLGNI
TP
//
