ID W5MPJ1_LEPOC Unreviewed; 425 AA.
AC W5MPJ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Dynein regulatory complex protein 10 {ECO:0000256|ARBA:ARBA00021752};
DE AltName: Full=IQ domain-containing protein D {ECO:0000256|ARBA:ARBA00032180};
GN Name=IQCD {ECO:0000313|Ensembl:ENSLOCP00000010300.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000010300.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000010300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. {ECO:0000256|ARBA:ARBA00003029}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000256|ARBA:ARBA00004611}.
CC -!- SIMILARITY: Belongs to the DRC10 family.
CC {ECO:0000256|ARBA:ARBA00009071}.
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DR EMBL; AHAT01005287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006640533.2; XM_006640470.2.
DR AlphaFoldDB; W5MPJ1; -.
DR STRING; 7918.ENSLOCP00000010300; -.
DR Ensembl; ENSLOCT00000010313.1; ENSLOCP00000010300.1; ENSLOCG00000008467.1.
DR GeneID; 102687592; -.
DR KEGG; loc:102687592; -.
DR CTD; 115811; -.
DR eggNOG; ENOG502QQS9; Eukaryota.
DR GeneTree; ENSGT00730000111354; -.
DR HOGENOM; CLU_637710_0_0_1; -.
DR InParanoid; W5MPJ1; -.
DR OMA; QFHNLVM; -.
DR OrthoDB; 1333124at2759; -.
DR Proteomes; UP000018468; Linkage group LG20.
DR Bgee; ENSLOCG00000008467; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.190; -; 1.
DR InterPro; IPR042815; DRC10.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR31598:SF1; DYNEIN REGULATORY COMPLEX PROTEIN 10; 1.
DR PANTHER; PTHR31598; IQ DOMAIN-CONTAINING PROTEIN D; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT REGION 255..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 324..386
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 425 AA; 47713 MW; C5358C06E4B06FE0 CRC64;
MAMEVAVLPV GGGCRQAASP SPQPRASAAR ESLKILDPAR KKLSSLETQR VAGVLDECIA
KVELVALLPT VLSGLERLSV GLGAELAGAL REHQRLGQML AALRERSQRQ GPGGENEDPR
LPGLEQALRS SLRSVLRHLR AHPSATHNLR GQAGAGGGAP GLAWGLAWGL TELRSLLFEK
LLTGPAEERE RSRYIQEVSL RHQNNVGLIS TLEREVAAAA RDRDAEISKK NEVIRKLKGS
LHQMEKISED FLKRTRQEAD KQTQSDHKAS ESRCGRMQQE MGQLRGRLCG LIAENRESEL
ALRKRKYKVE TEIENWIQKY DVDMGEKQTE LEELSAVYAE EKEELKELEE HFAVLEQEYS
QIMEERRLAR ERREEEERQL ALMTRAAILV QAFWRGYKVR KLMKSKKKGK KGKKGKKGKG
KKGKS
//
