ID W5MSB8_LEPOC Unreviewed; 505 AA.
AC W5MSB8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Complement C1q subcomponent subunit A {ECO:0000256|ARBA:ARBA00013456};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011277.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011277.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1,
CC the first component of the serum complement system. The collagen-like
CC regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2)
CC proenzyme complex, and efficient activation of C1 takes place on
CC interaction of the globular heads of C1q with the Fc regions of IgG or
CC IgM antibody present in immune complexes.
CC {ECO:0000256|ARBA:ARBA00002781}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; AHAT01012921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006638028.2; XM_006637965.2.
DR AlphaFoldDB; W5MSB8; -.
DR STRING; 7918.ENSLOCP00000011277; -.
DR Ensembl; ENSLOCT00000011293.1; ENSLOCP00000011277.1; ENSLOCG00000009248.1.
DR GeneID; 102694436; -.
DR KEGG; loc:102694436; -.
DR eggNOG; ENOG502RRBA; Eukaryota.
DR GeneTree; ENSGT00940000155435; -.
DR HOGENOM; CLU_001074_0_0_1; -.
DR InParanoid; W5MSB8; -.
DR OMA; IPFFCIC; -.
DR OrthoDB; 5361526at2759; -.
DR Proteomes; UP000018468; Linkage group LG14.
DR Bgee; ENSLOCG00000009248; Expressed in zone of skin and 1 other cell type or tissue.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IBA:GO_Central.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427:SF26; COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A; 1.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 4.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..505
FT /note="Complement C1q subcomponent subunit A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866583"
FT DOMAIN 340..473
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 34..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..55
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 52913 MW; 3C445547A0C7DA93 CRC64;
MTHCTTGLTM KTPLLLLCLQ LLWPLCGAMI TPHPPPERGG PEKPPNPPPN QDYHPMNPAD
QPHIYSPQRF PLTENDPFPG NISSRSFVPD MSQTVGLEPD MSYCQMLLES PVPPPIESVP
WFCLCMNCKG TMGPKGDRGE RGLPGHPGSP GPRGFSGFRG RPGFVGRQGL KGQKGDDGEK
GDQGVSGFRG AKGERGLKGD KGDQGLDGIP GLPGPQGEPG QCPVVCQGDL GLPGMTGLPG
PAGVRGPPGA DGVPGHPGQK GDMGSIGAPG PQGTQGPKGE HGAEGQCNCT DGEKGAHGEV
GPQGPPGNAG HPGAKGEAGL PGTKGEKGDE GLRGVPGPCS PTIQSGFSAA LDSIYPAPNR
PVPFGKVIYN LQGHFDPFNG IYMAPVNGTY VFSYQLVVFS KVLKVGLFLN FKPVVKTTEP
SDLGSASQMV VLQLSRGDRV WLQVKDTSTN GMYASSDSTS TFSGYLLYPD SCEMPLSRDF
PTYEEGDYSW GDEDEPPTRH STTPP
//