ID W5MSH0_LEPOC Unreviewed; 404 AA.
AC W5MSH0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Legumain prodomain domain-containing protein {ECO:0000259|Pfam:PF20985};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011329.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; AHAT01000011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MSH0; -.
DR STRING; 7918.ENSLOCP00000011329; -.
DR Ensembl; ENSLOCT00000011345.1; ENSLOCP00000011329.1; ENSLOCG00000009285.1.
DR eggNOG; KOG1348; Eukaryota.
DR GeneTree; ENSGT00940000154782; -.
DR HOGENOM; CLU_024160_2_0_1; -.
DR InParanoid; W5MSH0; -.
DR OMA; SKQWVLL; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000009285; Expressed in pharyngeal gill and 9 other cell types or tissues.
DR GO; GO:0005773; C:vacuole; IEA:GOC.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR CDD; cd21115; legumain_C; 1.
DR Gene3D; 1.10.132.130; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR048501; Legum_prodom.
DR InterPro; IPR046427; Legumain_prodom_sf.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR12000:SF21; LEGUMAIN-RELATED; 1.
DR Pfam; PF20985; Legum_prodom; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 307..400
FT /note="Legumain prodomain"
FT /evidence="ECO:0000259|Pfam:PF20985"
FT ACT_SITE 121
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 162
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ SEQUENCE 404 AA; 46337 MW; 9AFFD4B3F9AD63D1 CRC64;
KQWVLLAAGS KGWENYRHQA NVCHAYQIAK RNGIPDEQIV VMMYDDIAYN EENPYKGNII
NVPKGENVYI GVPKDYTGAE VSAENFLAVL KGDVSGVRKL EPKKVIRSGS YDTIFVYLTD
HGNSGIFTFP GSELLALELV ETVTQMSRNS QFSKMVIYIE SCHSGSMINN LPKDVNVYGV
SSARSDQATF ACYLDRDRNA YLSDEFSALW MHHIEMSDLE GETLQDQFNY VKKNMKHSFP
CQYGNRDIAR KTITEFLGKS AVPHIQRRSW ALKPTDITPS YNVPLEIQAN RIKRARDSAQ
KAIYEREYKN MLRTRKEIDK AVCAIAKDAC PSGAERALRE RRDPTQVREL KIITQHFRTC
CYDWNDTKYK YAISHMHVFV NLCESGTPVE RLVFFFEYIC TDQS
//
