ID W5MST8_LEPOC Unreviewed; 495 AA.
AC W5MST8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Forkhead box A1 {ECO:0000313|Ensembl:ENSLOCP00000011447.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011447.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011447.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; AHAT01003871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MST8; -.
DR STRING; 7918.ENSLOCP00000011447; -.
DR Ensembl; ENSLOCT00000011464.1; ENSLOCP00000011447.1; ENSLOCG00000009382.1.
DR eggNOG; KOG3563; Eukaryota.
DR GeneTree; ENSGT00940000162043; -.
DR HOGENOM; CLU_027910_4_1_1; -.
DR InParanoid; W5MST8; -.
DR OMA; WSSYYTD; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000009382; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0048319; P:axial mesoderm morphogenesis; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20038; FH_FOXA1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR013638; Fork-head_N.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018533; Forkhead_box_C.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR PANTHER; PTHR11829:SF195; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF08430; Forkhead_N; 1.
DR Pfam; PF09354; HNF_C; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 159..253
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 159..253
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 258..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 52735 MW; 29E2FA192AF5D29F CRC64;
MLGTVKMEGH ETPDWSSYYA EAQEVYSSVP NSSMNAGLGS MNSMNTYMGM STSGNMTSGS
FNMSYANTGL GAGLSPGTMA GMPPSGPGAM NGMTSGVSAM GAALSPSNMN AMPAPQASMN
ALTPYSSMSP AMSPMAYAQP NLNRARETKT FRRSYPHAKP PYSYISLITM AIQQAPSKML
TLSEIYQWIM DLFPYYRQNQ QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWALHPDSG
NMFENGCYLR RQKRFKCEKR LGGGKGPQDG RKEQPGGSGS PSTESSNAKP GPMESGSISS
SNQPPSPHSM DHGSGTAAGE LKPGGAQGHP AVSSAGPLAS VPLPPHSMAH EPQLHLKGDP
HYSFNHPFSI NNLMSSSEQQ HKLDLKAYEQ ALQYSSYGSG ISATLPLGST SMGGRASLDP
SAIEASYYQA HPPAAPTCAE RREKDEALAE RGCVQRPRRD SAVVSPSQTG ARAGEAGRKE
ISHILTEGRK SPGLG
//
