ID W5MTC8_LEPOC Unreviewed; 1755 AA.
AC W5MTC8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3 {ECO:0000313|Ensembl:ENSLOCP00000011637.1};
GN Name=TRPM3 {ECO:0000313|Ensembl:ENSLOCP00000011637.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011637.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011637.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AHAT01002941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000011637; -.
DR Ensembl; ENSLOCT00000011654.1; ENSLOCP00000011637.1; ENSLOCG00000009513.1.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000157366; -.
DR HOGENOM; CLU_001390_4_1_1; -.
DR InParanoid; W5MTC8; -.
DR OMA; XVIRHVG; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000009513; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 909..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1035..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1152..1177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..415
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 947..1186
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1279..1333
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1755 AA; 199377 MW; 1272AF76760DA065 CRC64;
MAKKKWGSRG EVERGCSTRD DASGRGASRG RFTESWKRLS SRQGSTKRSG LSSQQTLAQK
SWIERAFSKR ECVHIIVSAK DHYRCCCGRL IGQHVGLPPS ISSSQNDKNE RLAKNDSLPE
KWSISKHTQL SPTDAFGTIE FQGGGHSNKA MYVRVSYDTK PDLLLHLMTK EWQLDLPKLL
ISVHGGLQNF ELQPKLKQVF GKGLIKAAMT TGAWIFTGGV NTGVIRHVGD ALKDHASKSR
GKICTIGIAP WGIVENQEDL IGKDVVRPYQ TMSNPLSKLT VLNSLHSHFI LADNGTTGKY
GAEVKLRRQL EKHISLQKIN TRIGQGVPVV ALIVEGGPNV ISIVLEYLRD TPPVPVVVCD
GSGRASDILA FGHKYSEEGG VINESLRDQL LVTIQKTFNY SRTQAQHLFI ILMECMKKKE
LITVFRMGSE GHQDIDLAIL TALLKGANAS APDQLSLALA WNRVDIARSQ IFIYGQQWPV
GSLEQSMLDA LVLDRVDFVK LLIENGVSMH RFLTISRLEE LYNTRHGPSN TLYHLVRDVK
KGNLPPDYRI SLIDIGLVIE YLMGGAYRCN YTRKRFRTLY HNLFGPKRPK ALKLLGMEDD
LPMRRGRQKT TRKREEEVDI DLDDPEINHF PFPFHELMVW AVLMKRQKMA LFFWQHGEEA
MAKALVACKL CKAMAHEASE NDMVDDISQE LNHNSREFGQ LAVELLDQSY KQDEQMAMKL
LTYELKNWSN ATCLQLAVAA KHRDFIAHTC SQMLLTDMWM GRLRMRKNSG LKVILGLLLP
PSILSLEFKN KDEMSYMPQD QEAYLQEKET EEPEKPVKEK EEEDMEFTVR SYCGTQYNAV
AMLGKVNKES SRKKDVEEVQ TRHRFIPLGR KIYEFYNAPI VKFWFHTGGQ QCWGVVLAMN
CPRVNQIELM WLGYGKLPFI AFYFIICLIF SGLRYFKSDA ATMAYVGYLM LFNYIVLVKM
DLWPSPQEWI VIAYIFTNGI EKMREILMSE PGKLLQKVKV WLQEYWNITD LMAILIFSVG
LVLRLQDPPF MSYGRVIYCV NIIYWYIRLL DIFGVNKYLG PYVMMIGKMM IDMMYFVIIM
LVVLMSFGVA RQAILNPNED PSWMLARNIF FMPYWMIYGE VFADQIDPPC GQNITAEDGT
YVTLPPCKTG AWIVPAIMAC YLLVANILLV NLLIAVFNNT FFEVKSISNQ VWKFQRYQLI
MTFHERPVLP PPLIILSHMT MVLKHLCCRW RKHDDQDERD YGLKLFITED ELKKVHDFEE
QCIEEYFREK DDRFNSSNDE RIRVTSERVE NMAMRLEEVN EREHFMKASL QTVDIRLAQM
EEIIGRMASA LEKVAGVERG EMNKTRSRTS SDCTDTAYIL RQSSFNSQEG NAYKIQEAIE
QIGEESISPT SPTIIPRMRS HSFYVGGSRE KSGIDKIEGF FKERSLSLHR ASSSQSVAAS
KEPKPVPLPI NTLSVTHDSR RPSSCIDIYV SASDESHPAP ETDSAPLRLP LQRDSSLQSE
IMEAVLTYSA VTDKCSEATG VFEDSAAVDL SMGSSHVTES LQHWDLDPPQ HLERSKSSRY
LSAAPLFLED TPMVKSHSLM FTPRGYYGGL GVQVKAAEYT SITDCIDTRC VSACPASTQR
SGSPGGSFEK PQDLSISHPE REAELSHPGS DNEEPEPEPR RGGFGPGSTL MGPLCGPRSR
LERANSCSSE DSHTTNAHTR KSFSISDKMD RQRNSRNPFQ RSKSAKPEGK TDSFSMRKLT
KTSAFRSFDS RQNYT
//
