ID W5MUU5_LEPOC Unreviewed; 775 AA.
AC W5MUU5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=TLE family member 1, transcriptional corepressor {ECO:0000313|Ensembl:ENSLOCP00000012154.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012154.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; AHAT01003001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MUU5; -.
DR Ensembl; ENSLOCT00000012175.1; ENSLOCP00000012154.1; ENSLOCG00000009924.1.
DR GeneTree; ENSGT01030000234519; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000009924; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF29; TRANSDUCIN-LIKE ENHANCER PROTEIN 1; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 18..143
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 575..616
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 617..658
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 130..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..53
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 189..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 83760 MW; E7DF1BF72D8D0B85 CRC64;
MFPQSRHPTP HQAPGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN
AIIGVRGLPG LPPTQQQLQA QHLSHGHGPP VPLTPHPSGL HPPGLPHLGG SAGLLALSSA
LGGQPHLTVK EDKKNSHDPD HHRGERPGNC CISLRGSDKR RNGPEFSNDM KKRKVEDKDS
SHYDSDGDKS DDNLVVDVSN EDPASPRGTP AHSPRENGLE KNRLLKKDAS SSPASTASSG
SSSSLKSKEM SMHEKASTPV LKSSTPTPRA DMPTPGTSAT PGLRPSLSKP PSMELANQSA
AGLRTPLAVP GPYPGPFGMM PHSGMNGELT SPGAAYASLH NMSPQMSAAA AAAAVVAYGR
SPMVGFDPHP PMRVPGMPPN LAGIPGGKPA YSFHVTADGQ MQPVPFPPDA LIGPGIPRHA
RQINTLSHGE VVCAVTISNP TRHVYTGGKG CVKVWDISQP GNKSPVSQLD CLNRDNYIRS
CKLLPDGCTL IVGGEASTLS IWDLAAPTPR IKAELTSSAP ACYALAISPD SKVCFSCCSD
GNIAVWDLHN QTLVRQFQGH TDGASCIDIS NDGTKLWTGG LDNTVRSWDL REGRQLQQHD
FTSQIFSLGY CPTGEWLAVG MESSNVEVLH VNKPDKYQLH LHESCVLSLQ FAYCGKWFVS
TGKDNLLNAW RTPYGASIFQ SKESSSVLSC DISVDDKYIV TGSGDKKATV YEVIY
//
